Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, China.
Cancer Research Center Shandong University, Jinan, China.
PLoS One. 2018 Sep 5;13(9):e0203542. doi: 10.1371/journal.pone.0203542. eCollection 2018.
Medical carbon material has been extensively studied due to their excellent biological and mechanical properties. However, the dissociation of the surface carbon particles greatly limited the application of medical carbon material (MCM). To overcome this defect, we introduced the polydimethylsiloxane, a polymer-coating material (PCM) that possesses acceptable biocompatibility, into medical carbon material to prevent the shedding of carbon debris. Additionally, to reduce inflammatory reactions and increase surface hydrophilicity, ferulic acid, also called Chinese medicine coating material (CCM), was used to modify the surface of polymer-coating material. We investigated the proliferation and adhesion of NIH-3T3 cells onto MCM, PCM and CCM in vitro. We showed that CCM exhibited excellent biological activity to promote cell growth. Twelve weeks after CCM implantation, bone defects were repaired, and the material showed acceptable chemical stability. The results indicated that the CCM composite possesses excellent mechanical property and favorable biocompatibility, which can be used for clinical bone repair.
医用碳材料由于其优异的生物和机械性能而得到了广泛的研究。然而，表面碳颗粒的解离极大地限制了医用碳材料（MCM）的应用。为了克服这一缺陷，我们将具有良好生物相容性的聚二甲基硅氧烷（PDMS），一种聚合物涂层材料（PCM）引入到医用碳材料中，以防止碳颗粒的脱落。此外，为了减少炎症反应和增加表面亲水性，我们使用阿魏酸，也称为中药涂层材料（CCM），来修饰聚合物涂层材料的表面。我们研究了 NIH-3T3 细胞在 MCM、PCM 和 CCM 上的体外增殖和黏附。结果表明，CCM 表现出优异的生物活性，能够促进细胞生长。在 CCM 植入 12 周后，修复了骨缺损，并且材料表现出良好的化学稳定性。结果表明，CCM 复合材料具有优异的机械性能和良好的生物相容性，可用于临床骨修复。
