Pan Jiaqi, Cen Li, Chen Weixing, Yu Chaohui, Li Youming, Shen Zhe
Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, China.
Alcohol Alcohol. 2019 Jan 1;54(1):62-69. doi: 10.1093/alcalc/agy063.
Epidemiologic evidence on alcohol consumption increasing the risk of gastroesophageal reflux disease (GERD) is contradictory. This study aimed to investigate the correlation between alcohol consumption and GERD by a meta-analysis of observational studies.
Gastroesophageal reflux disease (GERD) is a prevalent disease, and the incidence is rising. We conducted a meta-analysis of observational studies, indicating that there was a significant association between alcohol consumption and the risk of GERD. This finding provides important implications for the prevention and control of GERD.
Two investigators retrieved relevant studies on PubMed, Cochrane and EMBASE, respectively. The summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by random effects model to assess the association. Heterogeneity was quantified using the Q statistic and I2. Subgroup analysis, publication bias and sensitivity analysis were also conducted.
Twenty-six cross-sectional studies and three case-control studies were included in the meta-analysis. The pooled random effects OR was 1.48 (95%CI, 1.31-1.67; I2 = 88.8%), in comparison between drinkers and non-/occasional drinkers. For reflux esophagitis and non-erosive reflux disease, two subtypes of GERD, the ORs were 1.78 (95%CI, 1.56-2.03; I2 = 87.5%) and 1.15 (95%CI, 1.04-1.28; I2 = 0.3%), respectively. In addition, the pooled OR for drinkers who drank <3-5 times or days per week was 1.29 (95%CI, 1.14-1.46; I2 = 35.5%), while for those who drank more frequently, the OR was 2.12 (95%CI, 1.63-2.75; I2 = 55.1%). Dose-response analysis showed a linear association between alcohol consumption and GERD (Pfornonlinearity=0.235). The pooled OR for a 12.5 g/day increment of alcohol was 1.16 (95%CI, 1.07-1.27; P = 0.001).
This meta-analysis provides evidence for a potential association between alcohol drinking and the risk of GERD. The increase in alcohol consumption and frequency showed a stronger association with GERD.
关于饮酒增加胃食管反流病（GERD）风险的流行病学证据相互矛盾。本研究旨在通过对观察性研究的荟萃分析来调查饮酒与GERD之间的相关性。
胃食管反流病（GERD）是一种常见疾病，且发病率正在上升。我们对观察性研究进行了荟萃分析，表明饮酒与GERD风险之间存在显著关联。这一发现为GERD的预防和控制提供了重要启示。
两名研究者分别在PubMed、Cochrane和EMBASE上检索相关研究。采用随机效应模型计算汇总比值比（OR）和95%置信区间（CI）以评估关联。使用Q统计量和I²对异质性进行量化。还进行了亚组分析、发表偏倚分析和敏感性分析。
荟萃分析纳入了26项横断面研究和3项病例对照研究。在饮酒者与不饮酒者/偶尔饮酒者的比较中，汇总随机效应OR为1.48（95%CI，1.31 - 1.67；I² = 88.8%）。对于GERD的两种亚型反流性食管炎和非糜烂性反流病，OR分别为1.78（95%CI，1.56 - 2.03；I² = 87.5%）和1.15（95%CI，1.04 -
