Herdiana Yedi
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Risk Manag Healthc Policy. 2025 Jan 18;18:217-237. doi: 10.2147/RMHP.S495493. eCollection 2025.
Ethanol, a bioactive compound prevalent in both social and industrial applications, is present in alcoholic beverages as well as a range of everyday products. In food, ethanol functions primarily as an additive or a by-product of fermentation, while in pharmaceuticals and cosmetics, it serves as a solvent or preservative. Despite its widespread use, three critical research gaps exist in current literature. First, existing research focuses predominantly on single-sector analyses, overlooking the cumulative effects of cross-sectoral ethanol exposure. Second, despite growing global market integration, there is limited understanding of how cultural and religious requirements influence ethanol-related regulations and product formulations. Third, current economic models fail to integrate both health impact costs and cultural compliance expenses, hindering effective policy development. The World Health Organization has determined that no amount of alcohol consumption can be considered entirely safe, as ethanol's health impacts include contributions to chronic diseases, neurotoxicity, and potential carcinogenic effects. These risks are compounded by the pervasive and often unrecognized presence of ethanol in various products, particularly affecting vulnerable populations. The economic burden associated with alcohol-related issues, including lost productivity and healthcare costs, highlights the necessity for robust public health strategies and stringent regulatory guidelines. This review investigates ethanol's role across multiple domains, emphasizing its presence in food, medicine, cosmetics, and industrial products, and evaluates its broader implications for public health, cultural practices, and economic impact. This review recommend implementing standardized labeling systems, establishing cultural-sensitive alternatives in product formulations, and developing harmonized international guidelines for ethanol use across industries.
乙醇是一种在社会和工业应用中普遍存在的生物活性化合物,存在于酒精饮料以及一系列日常产品中。在食品中,乙醇主要作为添加剂或发酵副产物发挥作用,而在药品和化妆品中,它用作溶剂或防腐剂。尽管乙醇应用广泛,但当前文献存在三个关键研究空白。首先,现有研究主要集中在单部门分析,忽视了跨部门乙醇暴露的累积影响。其次,尽管全球市场一体化不断发展,但对于文化和宗教要求如何影响乙醇相关法规及产品配方的理解有限。第三,当前经济模型未能将健康影响成本和文化合规成本纳入考量,阻碍了有效的政策制定。世界卫生组织已确定,无论饮酒量多少都不能被认为是完全安全的,因为乙醇对健康的影响包括导致慢性病、神经毒性以及潜在致癌作用。乙醇在各类产品中普遍存在且往往未被察觉,这加剧了这些风险,尤其对弱势群体影响较大。与酒精相关问题(包括生产力损失和医疗成本)相关的经济负担凸显了强有力的公共卫生策略和严格监管准则的必要性。本综述调查了乙醇在多个领域的作用,强调其在食品、药品、化妆品和工业产品中的存在,并评估其对公共卫生、文化习俗和经济影响的更广泛意义。本综述建议实施标准化标签系统,在产品配方中建立对文化敏感的替代方案,并制定跨行业统一的乙醇使用国际准则。