Filate Mersha, Mehari Zelalem, Alemu Yihun Mulugeta
Department of Statistics, Jimma University, Jimma, Ethiopia.
Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
BMJ Open. 2018 Sep 5;8(9):e019076. doi: 10.1136/bmjopen-2017-019076.
To describe the association between change in body weight and sputum smear conversion and to identify factors linked with body weight and sputum smear conversion in Jimma University Specialized Hospital, Southwest Ethiopia.
A retrospective follow-up study.
Teaching hospital in Southwest Ethiopia.
A total of 450 patients with tuberculosis (TB) were included in the follow-up between 2011 and 2013.
The association between body weight and sputum conversion was measured using joint modelling.
The association between change in body weight and change in sputum conversion was -0.698 (p<0.001). A strong inverse association between change in body weight and change in sputum conversion was observed. The study variables sex, age, type of TB, HIV status, dose of anti-TB drug and length of enrolment to TB treatment were significantly associated with change in body weight of patients with TB. The study variables age, type of TB, dose of anti-TB drug and length of enrolment were significantly associated with change in sputum status of patients with TB.
Among patients with TB who were on anti-TB treatment, increase in body weight and positive sputum status were inversely related over time. TB prevention and control strategies should give emphasis on factors such as female sex, older age, non-pulmonary positive type of TB, HIV-positive, lower dose of anti-TB drug and length of enrolment to TB treatment during monitoring of trends in body weight and sputum status.
描述体重变化与痰涂片转阴之间的关联，并确定埃塞俄比亚西南部吉马大学专科医院中与体重及痰涂片转阴相关的因素。
一项回顾性随访研究。
埃塞俄比亚西南部的教学医院。
2011年至2013年期间共有450例结核病患者纳入随访。
采用联合模型测量体重与痰涂片转阴之间的关联。
体重变化与痰涂片转阴变化之间的关联为-0.698（p<0.001）。观察到体重变化与痰涂片转阴变化之间存在强烈的负相关。研究变量性别、年龄、结核病类型、艾滋病毒感染状况、抗结核药物剂量以及开始结核病治疗的时间与结核病患者体重变化显著相关。研究变量年龄、结核病类型、抗结核药物剂量以及开始治疗的时间与结核病患者痰涂片状况变化显著相关。
在接受抗结核治疗的结核病患者中，随着时间推移，体重增加与痰涂片阳性状况呈负相关。在监测体重和痰涂片状况趋势时，结核病预防和控制策略应重视女性、老年、非肺部阳性型结核病、艾滋病毒阳性、抗结核药物剂量较低以及开始结核病治疗的时间等因素。
