Department of Preventive and Social Medicine, JIPMER, Puducherry 605006, India.
Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA.
J Public Health (Oxf). 2023 Aug 28;45(3):545-552. doi: 10.1093/pubmed/fdac141.
Tuberculosis (TB) is well-known for causing wasting. Patients on treatment gain weight and weight loss is associated with unfavorable treatment outcomes. There is limited description of weight loss and its predictors during intensive treatment phase. The objective of this study was to assess the predictors of weight loss during intensive phase and to see if there is any association exists with sputum conversion at the end of intensive phase of treatment.
Data collected as a part of the prospective TB cohort (Regional Prospective Observational Research for TB India Phase 1) conducted in Pondicherry, Cuddalore and Viluppuram districts of Tamil Nadu were used for this study. Sputum smear and body weight comparison were made in the baseline and at the end of second month of treatment.
In all, 726 participants had weight measurements at the two time points and 18.7% had weight loss; mean weight lost being 2.3 kg (SD 3.05). Mean weight loss was more among males (2.4 kg, SD 3.2), diabetics (2.8 kg, SD 3.9) and alcoholics (2.1 kg, SD 2.4). Alcohol consumption was the only predictor of weight loss after adjusting for age, diabetes, marital status and BMI (aRR 1.52, P 0.02). Weight loss was not associated with sputum conversion at the end of second month.
Alcohol use emerged as the major predictor for weight loss during intensive phase.
结核病（TB）以导致消瘦而闻名。接受治疗的患者体重增加，而体重减轻与治疗结果不佳有关。在强化治疗阶段，对体重减轻及其预测因素的描述有限。本研究的目的是评估强化治疗期间体重减轻的预测因素，并观察其与强化治疗期末痰转化是否存在关联。
本研究使用了在印度泰米尔纳德邦本地治里、古德洛尔和维鲁普兰区进行的前瞻性结核病队列研究（印度区域前瞻性观察性结核病研究 1）中收集的数据。在基线和治疗第二个月结束时进行痰涂片和体重比较。
共有 726 名参与者在两个时间点进行了体重测量，其中 18.7%的人体重减轻；平均体重减轻 2.3 公斤（SD 3.05）。男性（2.4 公斤，SD 3.2）、糖尿病患者（2.8 公斤，SD 3.9）和酗酒者（2.1 公斤，SD 2.4）体重减轻的平均值更高。在调整年龄、糖尿病、婚姻状况和 BMI 后，饮酒是体重减轻的唯一预测因素（aRR 1.52，P 0.02）。体重减轻与治疗第二个月末的痰转化无关。
在强化治疗期间，酒精使用成为体重减轻的主要预测因素。
