Pileni M P, Santus R, Land E J
Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Jul;32(1):23-32. doi: 10.1080/09553007714550731.
The reactivity of N'-formylkynurenine (FK) derivatives towards eaq has been investigated. The reduced transient species have been characterized (lambda max approximately 340, 440 nm, epsilon lambda max approximately 3000-1000 M-1 cm-1, pKa approximately 7.8). Owing to the strong FK electron affinity, electron-transfer reactions occur from purine (except guanine) and pyrimidine electron adducts to FK (k approximately 2-7 x 10(9) M-1 s-1). As some FK derivatives bind to DNA (or polynucleotides) the protective effect of complexation on FK-DNA (or polynucleotides) adduct formation has been investigated.
已对N'-甲酰基犬尿氨酸（FK）衍生物与水合电子（eaq）的反应活性进行了研究。已对还原的瞬态物种进行了表征（最大吸收波长约为340、440 nm，最大摩尔吸光系数约为3000 - 1000 M-1 cm-1，pKa约为7.8）。由于FK具有很强的电子亲和力，电子转移反应从嘌呤（鸟嘌呤除外）和嘧啶电子加合物发生到FK（速率常数k约为2 - 7×10(9) M-1 s-1）。由于一些FK衍生物与DNA（或多核苷酸）结合，因此研究了络合对FK - DNA（或多核苷酸）加合物形成的保护作用。
