Jacob Louis, John Mara, Kalder Matthias, Kostev Karel
Faculty of Medicine, University of Paris 5, Paris, France.
Department of Gynecology and Obstetrics, Philipps University of Marburg, Marburg, Germany.
Curr Med Mycol. 2018 Mar;4(1):6-11. doi: 10.18502/cmm.4.1.27.
To the best of our knowledge, no information is available regarding the treatment of vulvovaginal candidiasis in gynecological practices. The goal of this study was to analyze the prevalence of vulvovaginal candidiasis (VVC) and the drugs prescribed for the treatment of this condition in women followed in gynecological practices in Germany.
All the women followed in 262 gynecological practices between November 2014 and October 2016 were included in this study. The first outcome was the prevalence of patients diagnosed with VVC during this period. The second outcome was the prevalence of women with VVC who received an appropriate vaginal or systemic antimycotic prescription within 30 days after their first VVC diagnosis. Covariables included the use of gynecological/systemic antibiotics, consumption of oral/vaginal contraceptives, cancer, pregnancy, diabetes, and psychiatric diseases including depression, anxiety, and adjustment and somatoform disorders.
Between 2014 and 2016, 954,186 women were followed in gynecological practices, and 50,279 (5.3%) women were diagnosed with VVC during the same period. The use of gynecological antibiotics (OR=2.88), systemic antibiotics (OR=1.45), oral contraceptives (OR=1.74), and vaginal contraceptives (OR=1.84) were associated with an increase in the risk of VVC diagnosis. Cancer (OR=1.20) and pregnancy (OR=1.59) were additional risk factors. Approximately 75% of women diagnosed with VVC received an antimycotic prescription. The three most frequently prescribed drugs were clotrimazole (72%), fluconazole (14%), and nystatin (6%).
More than 5% of women were diagnosed with VVC and the majority of them received an appropriate prescription.
据我们所知，目前尚无关于妇科门诊中外阴阴道念珠菌病治疗情况的信息。本研究的目的是分析德国妇科门诊中女性外阴阴道念珠菌病（VVC）的患病率以及用于治疗该病的药物。
本研究纳入了2014年11月至2016年10月期间在262家妇科门诊就诊的所有女性。第一个结果是在此期间被诊断为VVC的患者患病率。第二个结果是首次诊断为VVC后30天内接受适当阴道或全身抗真菌药物处方的VVC女性患病率。协变量包括使用妇科/全身抗生素、口服/阴道避孕药、癌症、妊娠、糖尿病以及包括抑郁症、焦虑症、适应障碍和躯体形式障碍在内的精神疾病。
2014年至2016年期间，妇科门诊共随访了954,186名女性，同期有50,279名（5.3%）女性被诊断为VVC。使用妇科抗生素（OR = 2.88）、全身抗生素（OR = 1.45）、口服避孕药（OR = 1.74）和阴道避孕药（OR = 1.84）与VVC诊断风险增加相关。癌症（OR = 1.20）和妊娠（OR = 1.59）是另外的风险因素。大约75%被诊断为VVC的女性接受了抗真菌药物处方。最常开具的三种药物是克霉唑（72%）、氟康唑（14%）和制霉菌素（6%）。
超过5%的女性被诊断为VVC，且大多数患者接受了适当的处方。
