Ruhnke Markus, Groll Andreas H, Mayser Peter, Ullmann Andrew J, Mendling Werner, Hof Herbert, Denning David W
MVZ Hematology & Oncology, Paracelsus-Kliniken, Osnabrueck, Germany.
Department of Pediatric Hematology and Oncology, Center for Bone Marrow Transplantation, University Children's Hospital, Muenster, Germany.
Mycoses. 2015 Oct;58 Suppl 5:22-8. doi: 10.1111/myc.12392.
In the late 1980's, the incidence of invasive fungal diseases (IFDs) in Germany was estimated with 36.000 IFDs per year. The current number of fungal infections (FI) occurring each year in Germany is still not known. In the actual analysis, data on incidence of fungal infections in various patients groups at risk for FI were calculated and mostly estimated from various (mostly national) resources. According to the very heterogenous data resources robust data or statistics could not be obtained but preliminary estimations could be made and compared with data from other areas in the world using a deterministic model that has consistently been applied in many countries by the LIFE program ( www.LIFE-worldwide.org). In 2012, of the 80.52 million population (adults 64.47 million; 41.14 million female, 39.38 million male), 20% are children (0-14 years) and 16% of population are ≥65 years old. Using local data and literature estimates of the incidence or prevalence of fungal infections, about 9.6 million (12%) people in Germany suffer from a fungal infection each year. These figures are dominated (95%) by fungal skin disease and recurrent vulvo-vaginal candidosis. In general, considerable uncertainty surrounds the total numbers because IFDs do not belong to the list of reportable infectious diseases in Germany and most patients were not hospitalised because of the IFD but a distinct underlying disease.
在20世纪80年代后期，据估计德国侵袭性真菌病（IFD）的发病率为每年36000例。德国每年发生的真菌感染（FI）的实际数量仍不清楚。在实际分析中，计算了各有真菌感染风险的患者群体中真菌感染的发病率数据，且大多是根据各种（主要是国家层面的）资源估算得出的。由于数据资源非常多样化，无法获得可靠的数据或统计数据，但可以进行初步估算，并使用LIFE项目（www.LIFE-worldwide.org）在许多国家一直应用的确定性模型，与世界其他地区的数据进行比较。2012年，在8052万人口中（成年人6447万；女性4114万，男性3938万），20%为儿童（0至14岁），16%的人口年龄≥65岁。利用当地数据以及关于真菌感染发病率或患病率的文献估计，德国每年约有960万（12%）人患有真菌感染。这些数字中，真菌性皮肤病和复发性外阴阴道念珠菌病占主导（95%）。总体而言，由于侵袭性真菌病不属于德国应报告的传染病名单，且大多数患者并非因侵袭性真菌病住院，而是因某种明确的基础疾病住院，因此总数存在很大的不确定性。
