Machinami R, Kikuchi F
Pathol Res Pract. 1986 Jun;181(3):357-64. doi: 10.1016/S0344-0338(86)80121-2.
A case of alveolar soft part sarcoma was studied by light and electron microscopy and by electron microscopic enzyme histochemistry of adenosine triphosphatase (ATPase) and 5'nucleotidase(5'Nase). The tumor showed distinct alveolar pattern and diastase resistant PAS positive crystalline inclusions were found in the cytoplasm. Ultrastructurally, characteristic rhomboid crystals and dense granules were observed and they were positive for Mg++- and Ca++-ATPases but negative for 5'Nase. Tumor cell membrane also showed positive activity of ATPase in addition to 5'Nase. These results would support the myogenous derivation of alveolar soft part sarcoma.
通过光学显微镜、电子显微镜以及三磷酸腺苷酶（ATPase）和5'-核苷酸酶（5'Nase）的电子显微镜酶组织化学研究了1例肺泡软组织肉瘤。肿瘤呈现出明显的肺泡样结构，且在细胞质中发现了抗淀粉酶的PAS阳性结晶包涵体。超微结构上，观察到特征性的菱形晶体和致密颗粒，它们对Mg++-ATP酶和Ca++-ATP酶呈阳性反应，但对5'Nase呈阴性反应。肿瘤细胞膜除了对5'Nase呈阳性外，对ATPase也表现出阳性活性。这些结果支持肺泡软组织肉瘤的肌源性起源。
