Betsholtz C, Johnsson A, Heldin C H, Westermark B
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6440-4. doi: 10.1073/pnas.83.17.6440.
Simian sarcoma virus, an acutely transforming primate retrovirus with capacity to induce gliomas and sarcomas in experimental animals, has acquired its transforming properties by transducing the cellular gene sequences that encode one of the constituent chains of platelet-derived growth factor. Suramin, a drug used in the treatment of trypanosomiasis and onchocerciasis, has previously been reported to inhibit the interaction of platelet-derived growth factor with its cell surface receptor. We show here that suramin efficiently reverts the simian sarcoma virus-induced transformed phenotype in human and rat fibroblasts and propose that this is due to neutralization of an externalized v-sis product. Moreover, we show that suramin inhibits the action of a broad spectrum of growth factors.
猿猴肉瘤病毒是一种急性转化的灵长类逆转录病毒，能够在实验动物中诱发胶质瘤和肉瘤，它通过转导编码血小板衍生生长因子其中一条组成链的细胞基因序列而获得了转化特性。苏拉明是一种用于治疗锥虫病和盘尾丝虫病的药物，此前有报道称它能抑制血小板衍生生长因子与其细胞表面受体的相互作用。我们在此表明，苏拉明能有效逆转猿猴肉瘤病毒在人及大鼠成纤维细胞中诱导的转化表型，并提出这是由于中和了一种细胞外的v-sis产物。此外，我们还表明苏拉明能抑制多种生长因子的作用。
