Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Cell Physiol. 2019 Mar;234(3):2447-2459. doi: 10.1002/jcp.27289. Epub 2018 Sep 6.
Over the past decade, a wide range of scientific investigations have been performed to reveal neuropathological aspects of cognitive disorders; however, only limited therapeutic approaches currently exist. The failures of conventional therapeutic options as well as the predicted dramatic rise in the prevalence of cognitive decline in the coming future show the necessity for novel therapeutic agents. Recently, a wide range of research has focused on pharmacological activities of green tea catechins worldwide. Current investigations have clarified mechanistic effects of the catechins in inflammatory cascades, oxidative damages, different cellular transcription as well as transduction pathway in various body systems. It has been demonstrated that green tea polyphenols prevent age-related neurodegeneration through improvement of endogenous antioxidant defense mechanisms, modulation of neural growth factors, attenuation of neuroinflammatory pathway, and regulation of apoptosis. The catechins exhibited beneficial effects in cellular and animal models of neurodegenerative diseases including Alzheimer's disease, MS, and Parkinson's disease. The present review discusses the current pharmacological targets, which can be involved in the treatment of cognitive decline and addresses the action of catechin derivatives elicited from green tea on the multiple neural targets.
在过去的十年中，进行了广泛的科学研究以揭示认知障碍的神经病理学方面；然而，目前仅存在有限的治疗方法。常规治疗方法的失败以及未来预期的认知能力下降的患病率的显著上升表明需要新型治疗剂。最近，全世界范围内的广泛研究都集中在绿茶儿茶素的药理学活性上。目前的研究已经阐明了儿茶素在炎症级联反应、氧化损伤、不同细胞转录以及各种身体系统中的转导途径中的作用机制。已经证明，绿茶多酚通过改善内源性抗氧化防御机制、调节神经生长因子、减弱神经炎症途径以及调节细胞凋亡来预防与年龄相关的神经退行性变。儿茶素在包括阿尔茨海默病、多发性硬化症和帕金森病在内的神经退行性疾病的细胞和动物模型中表现出有益的作用。本综述讨论了可能参与治疗认知能力下降的当前药理学靶点，并探讨了绿茶衍生的儿茶素衍生物对多种神经靶点的作用。
