Farkhondeh Tahereh, Yazdi Hanieh Shaterzadeh, Samarghandian Saeed
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Research Center of Pardis Hospital, Mashhad, Iran.
Curr Drug Discov Technol. 2019;16(1):57-65. doi: 10.2174/1570163815666180219115453.
The therapeutic strategies to manage neurodegenerative diseases remain limited and it is necessary to discover new agents for their prevention and control. Oxidative stress and inflammation play a main role in the pathogenesis of neurodegenerative diseases. The aim of this study is to review the effects of green tea catechins against the Neurodegenerative Diseases.
In this study, we extensively reviewed all articles on the terms of Green tea, catechins, CNS disorders, and different diseases in PubMed, Science Direct, Scopus, and Google Scholar databases between the years 1990 and 2017.
The present study found that catechins, the major flavonoids in green tea, are powerful antioxidants and radical scavengers which possess the potential roles in the management of neurodegenerative diseases. Catechins modulate the cellular and molecular mechanisms through the inflammation-related NF-κB and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways.
The findings of the present review shows catechins could be effective against neurodegenerative diseases due to their antioxidation and anti-inflammation effects and the involved biochemical pathways including Nrf2 and NF-kB signaling pathways.
治疗神经退行性疾病的策略仍然有限，因此有必要发现新的药物来预防和控制这些疾病。氧化应激和炎症在神经退行性疾病的发病机制中起主要作用。本研究的目的是综述绿茶儿茶素对神经退行性疾病的影响。
在本研究中，我们广泛检索了1990年至2017年间PubMed、Science Direct、Scopus和谷歌学术数据库中关于绿茶、儿茶素、中枢神经系统疾病和不同疾病的所有文章。
本研究发现，儿茶素作为绿茶中的主要黄酮类化合物，是强大的抗氧化剂和自由基清除剂，在神经退行性疾病的治疗中具有潜在作用。儿茶素通过炎症相关的核因子κB（NF-κB）和核因子红细胞2相关因子2（Nrf2）信号通路调节细胞和分子机制。
本综述的结果表明，儿茶素因其抗氧化和抗炎作用以及涉及的生化途径（包括Nrf2和NF-κB信号通路），可能对神经退行性疾病有效。
