College of Science, University of Shanghai for Science and Technology, Shanghai, 200093, P. R. China.
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, P. R. China.
Macromol Biosci. 2018 Oct;18(10):e1800206. doi: 10.1002/mabi.201800206. Epub 2018 Sep 6.
In this work, a novel kind of electrospun microfiber to deliver a photothermal agent and an anticancer drug to tumor sites is explored. Photothermal therapy agent (MoS nanosheets) and doxorubicin (DOX) are incorporated with poly(lactic-co-glycolic acid) (PLGA) microfiber via electrospinning a solution of PLGA, MoS , and DOX. The designed microfiber with uniform fibrous morphology and negligible in vitro/in vivo hemo-/histo-toxicity is used as a durable photothermal agent, which shows an excellent photothermal transform ability and acceptable photothermal stability in both the first and second near-infrared light (NIR I and II) biowindows. The synergistic in vivo tumor chemotherapy and photothermal therapy efficiency of the composite microfibers are studied in postoperative treatment of cancer. It is found that the tumor postoperative reoccurrence can be completely prohibited owing to the synergistic tumor therapy efficiency in both the NIR I and NIR II biowindows.
在这项工作中，探索了一种新型的电纺微纤维，用于将光热剂和抗癌药物递送到肿瘤部位。光热治疗剂（MoS 纳米片）和阿霉素（DOX）通过静电纺丝 PLGA、MoS 和 DOX 的溶液与聚乳酸-羟基乙酸共聚物（PLGA）微纤维结合。设计的具有均匀纤维形态和体外/体内血液/组织毒性可忽略不计的微纤维可用作耐用的光热剂，其在第一和第二近红外光（NIR I 和 NIR II）生物窗口中表现出优异的光热转换能力和可接受的光热稳定性。在癌症的术后治疗中研究了复合微纤维的体内协同肿瘤化疗和光热治疗效率。发现由于在 NIR I 和 NIR II 生物窗口中具有协同的肿瘤治疗效率，完全可以防止肿瘤术后复发。
