He Huacheng, Markoutsa Eleni, Zhan Yihong, Zhang Jiajia, Xu Peisheng
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, 715 Sumter St., Columbia, SC 29208, United States.
Department of Epidemiology and Biostatistics, University of South Carolina, 800 Sumter Street, Columbia, SC 29208, United States.
Acta Biomater. 2017 Sep 1;59:181-191. doi: 10.1016/j.actbio.2017.07.005. Epub 2017 Jul 5.
Most photothermal converting systems are not biodegradable, which bring the uneasiness when they are administered into human body due to the uncertainty of their fate. Hereby, we developed a mussel-inspired PLGA/polydopamine core-shell nanoparticle for cancer photothermal and chemotherapy. With the help of an anti-EGFR antibody, the nanoparticle could effectively enter head and neck cancer cells and convert near-infrared light to heat to trigger drug release from PLGA core for chemotherapy as well as ablate tumors by the elevated temperature. Due to the unique nanoparticle concentration dependent peak working-temperature nature, an overheating or overburn situation can be easily prevented. Since the nanoparticle was retained in the tumor tissue and subsequently released its payload inside the cancer cells, no any doxorubicin-associated side effects were detected. Thus, the developed mussel-inspired PLGA/polydopamine core-shell nanoparticle could be a safe and effective tool for the treatment of head and neck cancer.
The described EGFR targeted PLGA/polydopamine core-shell nanoparticle (PLGA/PD NP) is novel in the following aspects: Different from most photothermal converting nanomaterials, PLGA/PD NP is biodegradable, which eliminates the long-term safety concerns thwarting the clinical application of photothermal therapy. Different from most photothermal nanomaterials, upon NIR irradiation, PLGA/PD NP quickly heats its surrounding environment to a NP concentration dependent peak working temperature and uniquely keeps that temperature constant through the duration of light irradiation. Due to this unique property an overheating or overburn situation for the adjacent healthy tissue can be easily avoided. The PLGA/PD NP releases its payload through detaching PD shell under NIR laser irradiation. The EGFR-targeted doxorubicin-loaded PLGA/PD NP effectively eradicate head and neck tumor in vivo through the synergism of photothermal therapy and chemotherapy while not introducing doxorubicin associated cardiotoxicity.
大多数光热转换系统不可生物降解，当将它们注入人体时，因其命运的不确定性而带来不安。在此，我们开发了一种受贻贝启发的聚乳酸-羟基乙酸共聚物/聚多巴胺核壳纳米颗粒用于癌症光热治疗和化疗。在抗表皮生长因子受体（EGFR）抗体的帮助下，该纳米颗粒可有效进入头颈癌细胞，将近红外光转化为热量以触发聚乳酸-羟基乙酸共聚物核心中的药物释放用于化疗，并通过升高的温度消融肿瘤。由于独特的纳米颗粒浓度依赖性峰值工作温度特性，可轻松防止过热或过度灼烧情况。由于纳米颗粒保留在肿瘤组织中并随后在癌细胞内释放其负载物，未检测到任何与阿霉素相关的副作用。因此，所开发的受贻贝启发的聚乳酸-羟基乙酸共聚物/聚多巴胺核壳纳米颗粒可能是治疗头颈癌的安全有效工具。
所描述的EGFR靶向聚乳酸-羟基乙酸共聚物/聚多巴胺核壳纳米颗粒（PLGA/PD NP）在以下方面具有新颖性：与大多数光热转换纳米材料不同，PLGA/PD NP可生物降解，这消除了阻碍光热疗法临床应用的长期安全担忧。与大多数光热纳米材料不同，在近红外照射下，PLGA/PD NP迅速将其周围环境加热到纳米颗粒浓度依赖性峰值工作温度，并在光照持续时间内独特地保持该温度恒定。由于这种独特性质，可轻松避免相邻健康组织出现过热或过度灼烧情况。PLGA/PD NP在近红外激光照射下通过分离聚多巴胺壳层释放其负载物。EGFR靶向载有阿霉素的PLGA/PD NP通过光热疗法和化疗的协同作用在体内有效根除头颈肿瘤，同时不引入与阿霉素相关的心脏毒性。
