Gibbs D M
Psychoneuroendocrinology. 1986;11(2):131-9. doi: 10.1016/0306-4530(86)90048-x.
ACTH secretion is primarily controlled by hypothalamic secretion of corticotropin releasing factor (CRF) into pituitary portal blood. However arginine vasopressin (AVP) and oxytocin (OT) can modulate the actions of CRF and at times may be important mediators of stress-induced ACTH secretion. The relative contributions of CRF, AVP, and OT to the control of ACTH secretion vary with different types of stress. In general, AVP stimulates ACTH secretion in all species studied. OT also stimulates ACTH release in rats but is inhibitory in primates. The involvement of AVP and OT in the control of ACTH secretion may have important implications for physiological and pathological conditions associated with activation of the hypothalamo--hypophysial--adrenal cortical axis.
促肾上腺皮质激素（ACTH）的分泌主要受下丘脑分泌的促肾上腺皮质激素释放因子（CRF）进入垂体门脉血液的控制。然而，精氨酸血管加压素（AVP）和催产素（OT）可以调节CRF的作用，并且有时可能是应激诱导的ACTH分泌的重要介质。CRF、AVP和OT对ACTH分泌控制的相对贡献因应激类型不同而有所差异。一般来说，AVP在所有研究的物种中都能刺激ACTH分泌。OT在大鼠中也能刺激ACTH释放，但在灵长类动物中具有抑制作用。AVP和OT参与ACTH分泌的控制可能对与下丘脑 - 垂体 - 肾上腺皮质轴激活相关的生理和病理状况具有重要意义。
