Department of Biochemistry, University of Colorado, Boulder, CO 80309, USA.
Department of Biochemistry, University of Colorado, Boulder, CO 80309, USA; Howard Hughes Medical Institute.
Neuron. 2018 Sep 5;99(5):869-871. doi: 10.1016/j.neuron.2018.08.026.
Aggregation of microtubule-associated protein tau is the hallmark of tauopathies, including Alzheimer's disease. Eftekharzadeh et al. (2018) demonstrate that pathogenic tau alters nucleocytoplasmic transport by interacting with components of the nuclear pore complex, revealing a perturbation shared by multiple neurodegenerative diseases.
微管相关蛋白 tau 的聚集是包括阿尔茨海默病在内的 tau 病的标志。Eftekharzadeh 等人（2018 年）证明，致病性 tau 通过与核孔复合体的成分相互作用改变核质转运，揭示了多种神经退行性疾病共有的扰动。
