Vivantes Klinikum Neukölln, Department for Radiology and Interventional Therapy, Berlin, Germany.
Eur J Radiol. 2013 Nov;82(11):1853-9. doi: 10.1016/j.ejrad.2013.06.023. Epub 2013 Jul 29.
Mesenteric panniculitis (MP) is an underdiagnosed inflammatory condition of mesenteric adipose tissue. Prior studies suggested an association of MP with malignancy. To reassess this hypothesis, we performed the first matched case-control study comparing prevalence of malignancy and other disease in patients with and without MP.
With a keyword search we identified CT examinations of MP patients between 2010 and 2012. Each MP patient was matched with two control patients for age, gender, abdominal diameter and CT protocol. Manifestation and extent of mesenteric panniculitis was classified independently by two investigators according to established criteria. Concomitant disease, laboratory parameters and follow up CTs were recorded and analyzed for all patients.
77 of 13485 CT patients were diagnosed with MP (prevalence 0.58%). 50.6% of MP patients suffered from malignancy vs. 60.2% in the control group (p=0.157). Over up to 4 years of follow up in 35 of these 77 MP patients no association between development of MP and the course of tumor diseases could be identified. There was also no significant difference in the rate of frequent concomitant diseases such as hypertension, diabetes or previous surgery between the two groups.
In this first case-control-study we could show that, contrary to previous reports, mesenteric panniculitis is neither paraneoplastic nor is it associated with other diseases.
肠系膜脂膜炎（MP）是一种肠系膜脂肪组织的未被充分诊断的炎症性疾病。先前的研究表明 MP 与恶性肿瘤有关。为了重新评估这一假说，我们进行了首次匹配的病例对照研究，比较了 MP 患者和无 MP 患者恶性肿瘤和其他疾病的患病率。
通过关键词搜索，我们确定了 2010 年至 2012 年间 MP 患者的 CT 检查。每个 MP 患者都与两名年龄、性别、腹部直径和 CT 方案相匹配的对照患者相匹配。两名研究者根据既定标准独立对肠系膜脂膜炎的表现和程度进行分类。记录并分析了所有患者的并存疾病、实验室参数和随访 CT。
在 13485 例 CT 患者中，有 77 例被诊断为 MP（患病率为 0.58%）。50.6%的 MP 患者患有恶性肿瘤，而对照组为 60.2%（p=0.157）。在这些 77 名 MP 患者中的 35 名患者中，对他们进行了长达 4 年的随访，没有发现 MP 的发生与肿瘤疾病的发展之间存在关联。两组常见并存疾病（如高血压、糖尿病或既往手术）的发生率也无显著差异。
在这项首次病例对照研究中，我们可以表明，与先前的报告相反，肠系膜脂膜炎既不是副肿瘤性的，也与其他疾病无关。
