酒精在肝细胞癌发生和发展中的作用。
Role of alcohol in the development and progression of hepatocellular carcinoma.
作者信息
McKillop Iain H, Schrum Laura W, Thompson Kyle J
机构信息
Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203 USA.
Department of Medicine, Carolinas Medical Center, Charlotte, NC 28203 USA.
出版信息
Hepat Oncol. 2016 Jan;3(1):29-43. doi: 10.2217/hep.15.40. Epub 2015 Nov 30.
Abstract
Hepatocellular carcinoma (HCC) is a significant cause of cancer-related morbidity and mortality. Chronic, heavy ethanol consumption is a major risk for developing the worsening liver pathologies that culminate in hepatic cirrhosis, the leading risk factor for developing HCC. A significant body of work reports the biochemical and pathological consequences of ethanol consumption and metabolism during hepatocarcinogeneis. The systemic effects of ethanol means organ system interactions are equally important in understanding the initiation and progression of HCC within the alcoholic liver. This review aims to summarize the effects of ethanol-ethanol metabolism during the pathogenesis of alcoholic liver disease, the progression toward HCC and the importance of ethanol as a comorbid factor for HCC development.
摘要
肝细胞癌（HCC）是癌症相关发病和死亡的重要原因。长期大量饮酒是导致肝脏病理状况恶化的主要风险因素，最终会发展为肝硬化，而肝硬化是发生HCC的主要风险因素。大量研究报告了肝癌发生过程中乙醇摄入和代谢的生化及病理后果。乙醇的全身效应意味着器官系统相互作用在理解酒精性肝病中HCC的发生和发展过程中同样重要。本综述旨在总结酒精性肝病发病机制中乙醇-乙醇代谢的影响、向HCC的进展以及乙醇作为HCC发展的合并因素的重要性。
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