Aldemir Ramazan, Demirci Esra, Bayram Ayşe Kaçar, Canpolat Mehmet, Ozmen Sevgi, Per Hüseyin, Tokmakci Mahmut
Biomedical Device Technology Program, Erciyes University, Kayseri, Turkey.
Department of Child Psychiatry, School of Medicine, Erciyes University, Kayseri, Turkey.
Transl Neurosci. 2018 Sep 1;9:106-116. doi: 10.1515/tnsci-2018-0017. eCollection 2018.
The aim of this study is to evalute the effects of methylphenidate and atomoxetine treatments on electroencephalography (EEG) signals in volunteer children diagnosed with Attention Deficit and Hyperactivity Disorder(ADHD).
The study contained 40 children all of whom were between the ages of 7 and 17. The participants were classified into two groups as ADHD (n=20), which was in itself divided into two groups as ADHD-MPH (ADHD- Metylphenidate treatment) (n=10) and as ADHD-ATX (ADHD-Atomoxetin treatment) (n=10), and one control group (n=20). Following the first EEG recordings of the ADHD group, long-acting methylphenidate dose was applied to one ADHD group and atomoxetine dose was applied to the other ADHD group. The effect of optimal dosage is about for 4-6 weeks in general. Therefore, the response or lack of response to the treatment was evaluated three months after the beginning of the treatment.After methylphenidate and atomoxetine drug treatment, in order to obtain mean and maximum power values for delta, theta, alpha and beta band, the EEG data were analyzed.
The EEG power spectrum densities in all the bands yielded similar findings in both methylphenidate and atomoxetine. Although statistically significant frequency values of the electrodes were amplitude and maximally varied, in general, they appeared mostly at both frontal and temporal regions for methylphenidate and atomoxetine.
Especially, after atomoxetine treatment, Quantitative Electroencephalography (QEEG) rates at frontal area electrodes were found statistically more significant than methylphenidate QEEG rates. What has been researched in this study is not only whether QEEG is likely to support the diagnosis, but whether changes on QEEG by treatment may be related to the severity of ADHD as well.
本研究旨在评估哌甲酯和托莫西汀治疗对被诊断为注意力缺陷多动障碍（ADHD）的志愿儿童脑电图（EEG）信号的影响。
该研究纳入了40名年龄在7至17岁之间的儿童。参与者被分为两组，ADHD组（n = 20），该组又分为ADHD-MPH（ADHD-哌甲酯治疗）组（n = 10）和ADHD-ATX（ADHD-托莫西汀治疗）组（n = 10），以及一个对照组（n = 20）。在对ADHD组进行首次脑电图记录后，给其中一个ADHD组应用长效哌甲酯剂量，给另一个ADHD组应用托莫西汀剂量。一般来说，最佳剂量的效果约为4至6周。因此，在治疗开始三个月后评估对治疗的反应或无反应情况。在哌甲酯和托莫西汀药物治疗后，为了获得δ、θ、α和β波段的平均和最大功率值，对脑电图数据进行了分析。
哌甲酯和托莫西汀在所有波段的脑电图功率谱密度产生了相似的结果。尽管电极的统计显著频率值在幅度和最大值上有所不同，但总体而言，它们在哌甲酯和托莫西汀的情况下大多出现在额叶和颞叶区域。
特别是，在托莫西汀治疗后，发现额叶区域电极的定量脑电图（QEEG）率在统计学上比哌甲酯的QEEG率更显著。本研究不仅探讨了QEEG是否可能支持诊断，还探讨了治疗引起的QEEG变化是否也可能与ADHD的严重程度有关。
