D'Abreu Anelyssa, Friedman Joseph H
Department of Neurology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Department of Neurology, Butler Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Tremor Other Hyperkinet Mov (N Y). 2018 Aug 31;8:570. doi: 10.7916/D8FF58Z9. eCollection 2018.
Although tardive dyskinesia (TD) is most commonly defined as a movement disorder caused by chronic exposure to dopamine-receptor-blocking drugs (DRBDs), it has also been thought to result from exposure to some non-DRBDs.
We critiqued many reviews making the association between non-DRBDs and a TD-like syndrome and almost all case reports. We checked whether cases met criteria for the diagnosis of TD-like syndrome and whether DRBDs had been excluded.
We found that both tricyclic antidepressants and selective serotonin reuptake inhibitor antidepressants may unmask or exacerbate TD after prior exposure to or with concurrent use of DRBDs. We found support for its existence outside of this context to be extremely weak.
There is little evidence that drugs other than DRBDs by themselves cause a TD syndrome; most reported cases appear to occur as a result of a "priming" effect induced by a DRBD, which is later unmasked.
尽管迟发性运动障碍（TD）最常被定义为长期接触多巴胺受体阻断药物（DRBDs）引起的一种运动障碍，但也有人认为它是由接触某些非DRBDs导致的。
我们对许多将非DRBDs与类TD综合征联系起来的综述以及几乎所有病例报告进行了批判分析。我们检查了病例是否符合类TD综合征的诊断标准，以及是否排除了DRBDs。
我们发现，三环类抗抑郁药和选择性5-羟色胺再摄取抑制剂类抗抑郁药在先前接触或同时使用DRBDs后，可能会使TD症状显现或加重。我们发现，在此背景之外支持其存在的证据极其薄弱。
几乎没有证据表明非DRBDs自身会导致TD综合征；大多数报告的病例似乎是由DRBDs诱发的“激发”效应导致的，这种效应随后才显现出来。
