循环炎症生物标志物在胆囊癌中的诊断作用。
The diagnostic role of circulating inflammation-based biomarker in gallbladder carcinoma.
作者信息
Liu Xi-Fen, Zhou Lin-Ying, Wei Zi-Hao, Liu Jia-Xin, Li Ang, Wang Xiao-Zhong, Ying Hou-Qun
机构信息
Department of Clinical Laboratory, Jiangxi Province Key Laboratory of Laboratory Medicine, the second affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, PR China.
Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi, PR China.
出版信息
Biomark Med. 2018 Oct;12(10):1095-1103. doi: 10.2217/bmm-2018-0049. Epub 2018 Sep 7.
AIM
To investigate the diagnostic roles of circulating inflammatory biomarkers in gallbladder carcinoma (GBC).
PATIENTS & METHODS: Circulating inflammatory cell count, fibrinogen, albumin, carcinoembryonic antigen (CEA) and CA199 were measured, neutrophil-to-lymphocyte ratio (NLR), dNLR, PLR, LMR and Alb-to-fib (AFR) were calculated in 306 GBC patients, 306 healthy and 305 benign controls. The reciever operating characteristic curve was used to determine diagnostic accuracy of them.
RESULTS
The area under curves of combined AFR, dNLR and lymphocyte were 0.943 and 0.985 for diagnosis of GBC from healthy and polyp controls, area under curve of combined AFR, CEA and CA199 was 0.90 for diagnosis of GBC from the cholecystitis patients.
CONCLUSION
Circulating AFR combined with lymphocyte and dNLR or CEA and CA199 could effectively distinguish GBC from the healthy and benign controls.
目的
探讨循环炎症生物标志物在胆囊癌（GBC）中的诊断作用。
患者与方法
检测306例GBC患者、306例健康对照者及305例良性疾病对照者的循环炎症细胞计数、纤维蛋白原、白蛋白、癌胚抗原（CEA）和CA199，并计算中性粒细胞与淋巴细胞比值（NLR）、动态NLR（dNLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）及白蛋白与纤维蛋白原比值（AFR）。采用受试者工作特征曲线确定其诊断准确性。
结果
联合AFR、dNLR和淋巴细胞诊断GBC与健康对照及息肉对照的曲线下面积分别为0.943和0.985，联合AFR、CEA和CA199诊断GBC与胆囊炎患者对照的曲线下面积为0.90。
结论
循环AFR联合淋巴细胞和dNLR或CEA和CA199可有效区分GBC与健康及良性对照。
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