Department of Basic Sciences, Faculty of Allied Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
Immunology Research Center, BuAli Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2019 Mar;234(3):2386-2398. doi: 10.1002/jcp.27263. Epub 2018 Sep 7.
The increased incidence of allergic disorders may be the result of a relative fall in microbial induction in the intestinal immune system during infancy and early childhood. Probiotics have recently been proposed as viable microorganisms for the prevention and treatment of specific allergic diseases. Different mechanisms have been considered for this probiotic property, such as generation of cytokines from activated pro-T-helper type 1 after bacterial contact. However, the effects of its immunomodulatory potential require validation for clinical applications. This review will focus on the currently available data on the benefits of probiotics in allergy disease.
过敏疾病发病率的增加可能是由于婴儿期和幼儿期肠道免疫系统中微生物诱导的相对减少所致。益生菌最近被提议作为预防和治疗特定过敏性疾病的可行微生物。已经考虑了这种益生菌特性的不同机制，例如在细菌接触后从活化的 pro-T-helper 1 型细胞生成细胞因子。然而，其免疫调节潜力的影响需要为临床应用进行验证。这篇综述将重点介绍益生菌在过敏疾病方面的现有数据。
