对重伤患者宿主防御过程的系统研究。
A systematic study of host defense processes in badly injured patients.
作者信息
Polk H C, George C D, Wellhausen S R, Cost K, Davidson P R, Regan M P, Borzotta A P
出版信息
Ann Surg. 1986 Sep;204(3):282-99.
Abstract
A prospective study of factors predisposing to infection in badly injured patients has disclosed: the dominant roles of two specific parameters: monocyte antigen presenting capacity, and opsonic capacity of diluted serum; the potential value of further assessment of: the predictive value of plots of activated T-cells/total T-cells versus monocyte antigen presenting capacity, the apparent protective effect of the ability to sharply increase specific IgM in response to infection, and the apparent protective effect of cytomegalovirus (CMV) infection in the first 28 days after injury against major bacterial infection; the lack of value of analysis of other T- and B-cell subsets in such patients; and the need to clarify CMV and transfusion status with respect to interpretation of such data. The specific role of variable transfusion and of specific serum immunoglobulins will require further and more discriminating study.
摘要
一项针对重伤患者感染易患因素的前瞻性研究揭示了
两个特定参数的主导作用，即单核细胞抗原呈递能力和稀释血清的调理能力；进一步评估的潜在价值，即活化T细胞/总T细胞与单核细胞抗原呈递能力的关系图的预测价值、感染后特异性IgM急剧增加的能力的明显保护作用，以及伤后前28天巨细胞病毒（CMV）感染对主要细菌感染的明显保护作用；分析此类患者其他T细胞和B细胞亚群的无价值性；以及就此类数据的解释而言，需要明确CMV和输血状态。可变输血和特定血清免疫球蛋白的具体作用将需要进一步且更具区分性的研究。
相似文献
1
A systematic study of host defense processes in badly injured patients.对重伤患者宿主防御过程的系统研究。
Ann Surg. 1986 Sep;204(3):282-99.
2
Impact on the cytomegalovirus (CMV) viral load by CMV-specific T-cell immunity in recipients of allogeneic stem cell transplantation.异基因干细胞移植受者中巨细胞病毒（CMV）特异性T细胞免疫对CMV病毒载量的影响。
Bone Marrow Transplant. 2006 Nov;38(10):687-92. doi: 10.1038/sj.bmt.1705507. Epub 2006 Sep 25.
3
Cytomegalovirus infection in transplant recipients resolves when circulating gammadelta T lymphocytes expand, suggesting a protective antiviral role.当循环中的γδ T淋巴细胞扩增时，移植受者的巨细胞病毒感染得以缓解，这表明γδ T淋巴细胞具有抗病毒保护作用。
J Infect Dis. 2001 Sep 1;184(5):533-41. doi: 10.1086/322843. Epub 2001 Jul 31.
4
Human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection.成人异基因造血干细胞移植受者中人类巨细胞病毒特异性CD4+和CD8+ T细胞重建及病毒感染的免疫控制
Haematologica. 2008 Feb;93(2):248-56. doi: 10.3324/haematol.11912.
5
Evaluation of cytomegalovirus-specific T-cell reconstitution in patients after various allogeneic haematopoietic stem cell transplantation using interferon-gamma-enzyme-linked immunospot and human leucocyte antigen tetramer assays with an immunodominant T-cell epitope.使用干扰素-γ酶联免疫斑点法和人白细胞抗原四聚体分析法以及一个免疫显性T细胞表位，评估各类异基因造血干细胞移植术后患者的巨细胞病毒特异性T细胞重建情况。
Br J Haematol. 2005 Nov;131(4):472-9. doi: 10.1111/j.1365-2141.2005.05800.x.
6
Augmentation of virus-specific immunity after hematopoietic stem cell transplantation by adoptive T-cell therapy.通过过继性T细胞疗法增强造血干细胞移植后的病毒特异性免疫。
Hum Immunol. 2004 May;65(5):550-7. doi: 10.1016/j.humimm.2004.02.016.
7
Simultaneous activation of viral antigen-specific memory CD4+ and CD8+ T-cells using mRNA-electroporated CD40-activated autologous B-cells.使用经mRNA电穿孔的CD40激活的自体B细胞同时激活病毒抗原特异性记忆CD4+和CD8+ T细胞。
J Immunother. 2006 Sep-Oct;29(5):512-23. doi: 10.1097/01.cji.0000210385.48327.1e.
8
Major expansion of gammadelta T lymphocytes following cytomegalovirus infection in kidney allograft recipients.肾移植受者巨细胞病毒感染后γδ T淋巴细胞大量扩增。
J Infect Dis. 1999 Jan;179(1):1-8. doi: 10.1086/314568.
9
Deficiency of cytomegalovirus (CMV)-specific CD8+ T cells in patients presenting with late-onset CMV disease several years after transplantation.在移植数年出现迟发性巨细胞病毒（CMV）疾病的患者中，CMV特异性CD8 + T细胞缺乏。
Transpl Infect Dis. 2009 Feb;11(1):20-7. doi: 10.1111/j.1399-3062.2008.00344.x. Epub 2008 Sep 21.
10
Host defense response to cytomegalovirus in the central nervous system. Predominance of the monocyte.中枢神经系统对巨细胞病毒的宿主防御反应。单核细胞占优势。
Am J Pathol. 1989 Jan;134(1):71-8.
引用本文的文献
1
Mechanisms of immune suppression in sepsis/shock: one investigator's/lab group's experience (SLB 2024 legacy award presentation).脓毒症/休克中免疫抑制的机制：一位研究者/实验室团队的经验（SLB 2024传承奖颁奖演讲）
J Leukoc Biol. 2025 Aug 5;117(8). doi: 10.1093/jleuko/qiaf108.
2
The value of postoperative HLA-DR expression and high mobility group box 1 level in predictive diagnosis of sepsis in percutaneous nephrolithotomy surgery.术后 HLA-DR 表达和高迁移率族蛋白 B1 水平在经皮肾镜取石术术后脓毒症预测诊断中的价值。
Ren Fail. 2022 Dec;44(1):1338-1344. doi: 10.1080/0886022X.2022.2107541.
3
Potential Immune Indicators for Predicting the Prognosis of COVID-19 and Trauma: Similarities and Disparities.预测 COVID-19 和创伤预后的潜在免疫指标：相似性和差异性。
Front Immunol. 2022 Jan 20;12:785946. doi: 10.3389/fimmu.2021.785946. eCollection 2021.
4
Inflammation and Cell Death of the Innate and Adaptive Immune System during Sepsis.脓毒症时固有免疫和适应性免疫系统的炎症和细胞死亡。
Biomolecules. 2021 Jul 10;11(7):1011. doi: 10.3390/biom11071011.
5
Does Presence of Sepsis by Itself Predispose the Patients to HCAIs?脓毒症本身是否会使患者易患医院获得性感染？
Indian J Crit Care Med. 2021 Mar;25(3):253-254. doi: 10.5005/jp-journals-10071-23771.
6
The relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanically ventilated patients.通过体外刺激肿瘤坏死因子α水平测定的免疫状态与重症机械通气患者医院感染获得之间的关系。
Intensive Care Med Exp. 2020 Sep 16;8(1):55. doi: 10.1186/s40635-020-00344-w.
7
The role and function of IκKα/β in monocyte impairment.IKKα/β 在单核细胞损伤中的作用和功能。
Sci Rep. 2020 Jul 22;10(1):12222. doi: 10.1038/s41598-020-68018-x.
8
Flow Cytometry of CD64, HLA-DR, CD25, and TLRs for Diagnosis and Prognosis of Sepsis in Critically Ill Patients Admitted to the Intensive Care Unit: A Review Article.重症监护病房收治的危重症患者中，用于脓毒症诊断和预后评估的CD64、HLA-DR、CD25及Toll样受体的流式细胞术：一篇综述文章
Anesth Pain Med. 2018 Dec 5;8(6):e83128. doi: 10.5812/aapm.83128. eCollection 2018 Dec.
9
Reduced NLRP3 Gene Expression Limits the IL-1 Cleavage via Inflammasome in Monocytes from Severely Injured Trauma Patients.严重创伤患者单核细胞中 NLRP3 基因表达减少限制了白细胞介素-1 的切割。
Mediators Inflamm. 2018 May 9;2018:1752836. doi: 10.1155/2018/1752836. eCollection 2018.
10
Immunoparalysis in Pediatric Critical Care.儿科重症监护中的免疫麻痹
Pediatr Clin North Am. 2017 Oct;64(5):1089-1102. doi: 10.1016/j.pcl.2017.06.008. Epub 2017 Aug 18.
本文引用的文献
1
Epidemiology of trauma deaths.创伤死亡的流行病学
Am J Surg. 1980 Jul;140(1):144-50. doi: 10.1016/0002-9610(80)90431-6.
2
Causes of death after blunt trauma.钝性创伤后的死因。
J Trauma. 1982 Feb;22(2):141-6. doi: 10.1097/00005373-198202000-00011.
3
Disorders of phagocyte chemotaxis.吞噬细胞趋化性障碍。
Ann Intern Med. 1980 Apr;92(4):520-38. doi: 10.7326/0003-4819-92-4-520.
4
An assessment of the validity of the injury severity score when applied to gunshot wounds.对损伤严重度评分应用于枪伤时的有效性评估。
Injury. 1983 Jul;15(1):19-22. doi: 10.1016/0020-1383(83)90156-0.
5
6
7
Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.皮质类固醇抑制小鼠巨噬细胞Ia表达和白细胞介素1的产生。
J Immunol. 1982 Nov;129(5):1803-5.
8
Failure of delayed hypersensitivity skin testing to predict postoperative sepsis and mortality.迟发型超敏反应皮肤试验无法预测术后败血症和死亡率。
Br Med J (Clin Res Ed). 1982 Mar 20;284(6319):851-3. doi: 10.1136/bmj.284.6319.851.
9
Complement, opsonins, and the immune response to bacterial infection in burned patients.补体、调理素与烧伤患者对细菌感染的免疫反应
Ann Surg. 1980 Mar;191(3):323-9. doi: 10.1097/00000658-198003000-00011.
10
Failure of opsonization as a sign of lethal sepsis.调理作用失败作为致死性脓毒症的一个迹象。
J Infect Dis. 1984 Apr;149(4):651. doi: 10.1093/infdis/149.4.651.
Zotero 插件