Polk H C, George C D, Wellhausen S R, Cost K, Davidson P R, Regan M P, Borzotta A P
Ann Surg. 1986 Sep;204(3):282-99.
A prospective study of factors predisposing to infection in badly injured patients has disclosed: the dominant roles of two specific parameters: monocyte antigen presenting capacity, and opsonic capacity of diluted serum; the potential value of further assessment of: the predictive value of plots of activated T-cells/total T-cells versus monocyte antigen presenting capacity, the apparent protective effect of the ability to sharply increase specific IgM in response to infection, and the apparent protective effect of cytomegalovirus (CMV) infection in the first 28 days after injury against major bacterial infection; the lack of value of analysis of other T- and B-cell subsets in such patients; and the need to clarify CMV and transfusion status with respect to interpretation of such data. The specific role of variable transfusion and of specific serum immunoglobulins will require further and more discriminating study.
两个特定参数的主导作用，即单核细胞抗原呈递能力和稀释血清的调理能力；进一步评估的潜在价值，即活化T细胞/总T细胞与单核细胞抗原呈递能力的关系图的预测价值、感染后特异性IgM急剧增加的能力的明显保护作用，以及伤后前28天巨细胞病毒（CMV）感染对主要细菌感染的明显保护作用；分析此类患者其他T细胞和B细胞亚群的无价值性；以及就此类数据的解释而言，需要明确CMV和输血状态。可变输血和特定血清免疫球蛋白的具体作用将需要进一步且更具区分性的研究。
