Piette J, Decuyper J, Merville-Louis M P, Van de Vorst A
Biochimie. 1986 Jun;68(6):835-42. doi: 10.1016/s0300-9084(86)80098-0.
This survey focuses on recent developments in the field of the ultraviolet photochemistry and photobiology of phenothiazine derivatives. One of the major alterations introduced by this kind of photosensitized reaction is a covalent addition of the photosensitizer or one of its photoproducts onto the macromolecular target. This reaction has been observed with soluble and membrane proteins, lipids and DNA. In the latter case, the addition occurs at the level of guanine residues and leads to inhibition of DNA replication.
本综述聚焦于吩噻嗪衍生物的紫外光化学与光生物学领域的最新进展。这种光敏反应所引发的主要变化之一是光敏剂或其光产物之一与大分子靶点发生共价加成。已在可溶性蛋白、膜蛋白、脂质和DNA中观察到这种反应。在后一种情况下，加成发生在鸟嘌呤残基水平，并导致DNA复制受到抑制。
