DNA 双链断裂作为神经基因组改变、功能和疾病的驱动因素。
DNA double-strand breaks as drivers of neural genomic change, function, and disease.
机构信息
Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States.
Department of Neurological Surgery and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94158, United States.
出版信息
DNA Repair (Amst). 2018 Nov;71:158-163. doi: 10.1016/j.dnarep.2018.08.019. Epub 2018 Aug 23.
Abstract
Early work from about two decades ago implicated DNA double-strand break (DSB) formation and repair in neuronal development. Findings emerging from recent studies of DSBs in proliferating neural progenitors and in mature, non-dividing neurons suggest important roles of DSBs in brain physiology, aging, cancer, psychiatric and neurodegenerative disorders. We provide an overview of some findings and speculate on what may lie ahead.
摘要
早期约二十年前的工作表明，DNA 双链断裂（DSB）的形成和修复与神经元发育有关。最近对增殖中的神经祖细胞和成熟的、非分裂神经元中的 DSB 的研究结果表明，DSB 在大脑生理学、衰老、癌症、精神疾病和神经退行性疾病中具有重要作用。我们提供了一些研究结果的概述，并对未来可能的发展进行了推测。
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