Müller Simone, Heeren Tjebo F C, Nadal Jennifer, Charbel Issa Peter, Herrmann Philipp, Holz Frank G, Wabbels Bettina K
Department of Ophthalmology, University of Bonn, Bonn, Germany,
Department of Ophthalmology, University of Bonn, Bonn, Germany.
Ophthalmologica. 2019;241(3):121-129. doi: 10.1159/000492134. Epub 2018 Sep 7.
To investigate stereoscopic vision in patients with macular telangiectasia (MacTel) type 2 and correlate paracentral sensitivity loss to reduced stereoscopic function.
In a prospective single-center study, 50 patients with MacTel type 2 and 25 age-matched controls were investigated. Stereoscopic function was evaluated with Lang I, Titmus, and TNO tests. Sensitivity of the central 16° was tested using fundus-controlled perimetry (microperimetry). Functional loss was quantified as depth, size, and localization of scotomata.
Both the Titmus and the TNO test revealed significantly reduced stereoscopic vision in patients compared to controls (p < 0.0001 for both). This applied even to patients with only relative or monocular paracentral scotoma. A strong correlation was observed for reduced stereoscopic vision with horizontal scotoma size and with the distance of scotomata from the foveal center.
The results indicate that stereoscopic vision is impaired early in patients with MacTel type 2. A paracentral sensitivity loss, even if mild and limited to one eye, may considerably interfere with stereoscopic function despite normal visual acuity. Projection of paracentral scotomata within the patient's central visual field plays an important role in stereoscopic vision and should be considered when interpreting stereoscopic test results.
研究2型黄斑毛细血管扩张症（MacTel）患者的立体视觉，并将旁中心敏感度损失与立体视觉功能降低相关联。
在一项前瞻性单中心研究中，对50例2型MacTel患者和25例年龄匹配的对照者进行了研究。使用朗I、蒂特马斯和TNO测试评估立体视觉功能。使用眼底控制视野计（微视野计）测试中央16°的敏感度。功能损失以暗点的深度、大小和位置进行量化。
与对照组相比，蒂特马斯和TNO测试均显示患者的立体视觉显著降低（两者p < 0.0001）。这甚至适用于仅患有相对或单眼旁中心暗点的患者。观察到立体视觉降低与水平暗点大小以及暗点距黄斑中心的距离之间存在强烈相关性。
结果表明，2型MacTel患者的立体视觉在早期就受到损害。旁中心敏感度损失，即使轻微且仅限于一只眼睛，尽管视力正常，也可能会严重干扰立体视觉功能。旁中心暗点在患者中央视野内的投射在立体视觉中起重要作用，在解释立体视觉测试结果时应予以考虑。
