Alieva A S, Rotar O P, Orlov A V, Boyarinova M A, Moguchaya E V, Rogoza A N, Konradi A O, Shlyakhto E V
Almazov National Medical Research Centre, Saint Petersburg, Russia; Department of Pharmacological and Biomolecular Sciences (DisFeB), University of Milan, Milan, Italy.
Almazov National Medical Research Centre, Saint Petersburg, Russia.
Atheroscler Suppl. 2018 Sep;35:e1-e5. doi: 10.1016/j.atherosclerosissup.2018.08.001. Epub 2018 Aug 24.
The aim of the present study was to assess the prevalence of increased arterial stiffness by different diagnostic methods and its association with cardiovascular risk in Russian population-based cohort.
In terms of Russian epidemiological study ESSE-RF a random selection of 452 apparently healthy Saint-Petersburg inhabitants aged 25-65 years was performed. Fasting lipids, glucose and blood pressure measurements were performed. We used 3 diagnostic methods of arterial stiffness assessment: pulse wave velocity by applanation tonometry (SphygmoCor - PWV-S) and pulse wave velocity by volumetric sphygmography (VaSera - PWV-V), and cardio-ankle vascular index (CAVI) by VaSera.
341 (75,4%) had normal parameters of arterial stiffness assessed by all methods. Spearmen's coefficient of correlation and "kappa" coefficient for PWV-S and CAVI were 0,74 and 0,04, for PWV-S and PWV-V - 0,10 and 0,06, for CAVI and PWV-V - 0,28 and 0,03, respectively. There was a significant correlation between cardiovascular risk (defined by SCORE) and PWV-S (r = 0,38, p < 0,001) and a non-significant trend of increasing CAVI along with cardiovascular risk (r = 0,35, p = 0,14).
Different methods of arterial stiffness assessment showed a weak correlation with each other. Carotid-femoral pulse wave velocity detected by applanation tonometry is associated with high cardiovascular risk score and might be considered as better additional risk marker for cardiovascular risk stratification.
本研究旨在通过不同诊断方法评估俄罗斯基于人群队列中动脉僵硬度增加的患病率及其与心血管风险的关联。
在俄罗斯流行病学研究ESSE-RF中，随机选取了452名年龄在25至65岁之间、看似健康的圣彼得堡居民。进行了空腹血脂、血糖和血压测量。我们使用了3种动脉僵硬度评估诊断方法：应用压平式眼压计测量脉搏波速度（SphygmoCor - PWV-S）、应用容积脉搏波描记法测量脉搏波速度（VaSera - PWV-V）以及通过VaSera测量心踝血管指数（CAVI）。
341人（75.4%）通过所有方法评估的动脉僵硬度参数正常。PWV-S与CAVI的斯皮尔曼相关系数和“kappa”系数分别为0.74和0.04，PWV-S与PWV-V的分别为0.10和0.06，CAVI与PWV-V的分别为0.28和0.03。心血管风险（由SCORE定义）与PWV-S之间存在显著相关性（r = 0.38，p < 0.001），并且CAVI随心血管风险增加有不显著的趋势（r = 0.35，p = 0.14）。
不同的动脉僵硬度评估方法相互之间显示出较弱的相关性。通过压平式眼压计检测的颈股脉搏波速度与高心血管风险评分相关，可能被视为心血管风险分层的更好的附加风险标志物。
