Gomez-Sanchez Leticia, Garcia-Ortiz Luis, Patino-Alonso Maria C, Recio-Rodriguez José I, Frontera Guillermo, Ramos Rafel, Martí Ruth, Agudo-Conde Cristina, Rodriguez-Sanchez Emiliano, Maderuelo-Fernández Jose A, Gomez-Marcos Manuel A
Primary Care Research Unit, the Alamedilla Health Center.
J Atheroscler Thromb. 2015;22(9):901-11. doi: 10.5551/jat.28035. Epub 2015 May 20.
We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave velocity (PWV) and the central augmentation index (CAIx) that is independent of the subject's cardiovascular risk and pharmacological treatment.
The CAVI score was measured in 500 subjects using a VaSera device and the brachial ankle PWV (ba-PWV) was calculated. A carotid ultrasound was used to measure the IMT. A Mobil-O-Graph device was used to measure the carotid femoral PWV (cf-PWV) and the CAIx. The Framingham-D'Agostino and SCORE scales were used to measure the subject's cardiovascular risk.
The mean value of the CAVI score was 8.59 ± 1.1. IMT, CAIx and PWV maintained a positive association with the CAVI score (p ＜ 0.01) in a multiple linear regression analysis, after adjusting for the subject's cardiovascular risk, body mass index and pharmacological treatment. The cut-off level that gave the maxima sensitivity and specificity to detect a mean IMT of ＞ 0.90 mm was 8.95 (AUC=0.67) for the CAVI score, 8.85 (AUC=0.66) for cf-PWV and 15.10 (AUC=0.66) for ba-PWV. The cut-off to detect a maxima IMT of ＞ 0.90 mm was 8.60 (AUC=0.62) for the CAVI score, 8.85 (AUC=0.64) for cf-PWV and 15.75 (AUC=0.70) for ba-PWV.
There was a positive association of the CAVI score with vascular structure and function parameters that was independent of cardiovascular risk and any medications being used by the subject. The ability of the CAVI score to predict carotid atherosclerosis is similar to that of cf-PWV and ba-PWV in Caucasian adults.
我们评估了心踝血管指数（CAVI）评分与颈动脉内膜中层厚度（IMT）、脉搏波速度（PWV）和中心动脉增强指数（CAIx）之间是否存在独立于受试者心血管风险和药物治疗的关联。
使用VaSera设备测量500名受试者的CAVI评分，并计算肱踝脉搏波速度（ba-PWV）。采用颈动脉超声测量IMT。使用Mobil-O-Graph设备测量颈股脉搏波速度（cf-PWV）和CAIx。采用弗明汉-达戈斯蒂诺和SCORE量表测量受试者的心血管风险。
CAVI评分的平均值为8.59±1.1。在对受试者的心血管风险、体重指数和药物治疗进行校正后，在多元线性回归分析中，IMT、CAIx和PWV与CAVI评分保持正相关（p＜0.01）。检测平均IMT＞0.90 mm时，CAVI评分的截断水平为8.95（曲线下面积=0.67），cf-PWV为8.85（曲线下面积=0.66），ba-PWV为15.10（曲线下面积=0.66）。检测最大IMT＞0.90 mm时，CAVI评分的截断水平为8.60（曲线下面积=0.62），cf-PWV为8.85（曲线下面积=0.64），ba-PWV为15.75（曲线下面积=0.70）。
CAVI评分与血管结构和功能参数呈正相关，且独立于心血管风险和受试者正在使用的任何药物。在白种成年人中，CAVI评分预测颈动脉粥样硬化的能力与cf-PWV和ba-PWV相似。
