Eryilmaz Aylin, Cengiz Arzu, Basal Yesim, Meteoglu Ibrahim, Omurlu Imran Kurt, Yurekli Yakup
Department of Otorhinolaryngology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Department of Nuclear Medicine, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
J Cancer Res Ther. 2018 Jul-Sep;14(5):994-998. doi: 10.4103/0973-1482.179162.
To investigate the correlation between tumor stage, Ki-67, Bcl-2, hypoxia inducible factor-1α (HIF-1α), cyclin D1 and metabolic tumor volume (MTV), total lesion glycolysis (TLG), maximum standardized uptake value (SUV) measured by F fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in patients diagnosed with laryngeal cancer.
In this study, included 25 consecutive laryngeal cancer patients (2 women, 23 men) diagnosed and treated in the Otorhinolaryngology Department of our tertiary care center. All cases underwent F FDG PET/CT and SUV, mean standardized uptake value, MTV, and TLG values were calculated. Tumor staging was made and immunohistochemical staining was carried out for Ki-67, Bcl-2, HIF-1α and cyclin D1.
Eight (32%) patients had glottic laryngeal cancer, 6 (24%) had supraglottic laryngeal cancer and 11 (44%) had transglottic laryngeal cancer. Cyclin D1 was significantly correlated with MTV (r = 0.45, P = 0.03), TLG (r = 0.492, P = 0.01) and T-stage (r = 0.483, P = 0.02). Bcl-2 was significantly correlated with SUV (r = -0.41, P = 0.05) and tumor stage (r = -0.442, P = 0.03). MTV and TLG are significantly correlated with nodal stage (r = 0.422, P = 0.04, r = 0.419, P = 0.04), while TLG (r = 0.403, P = 0.05) and SUV (r = 0.440, P = 0.03) were correlated with tumor stage.
Our results indicated that biomarkers such as cyclin D1 and Bcl-2 were correlated with measures such as MTV, TLG, and SUV in F-FDG PET/CT. Integrative and combined evaluation of biomarkers and imaging data derived from F-FDG PET/CT are important for staging and appropriate management of patients with laryngeal cancer.
探讨喉癌患者肿瘤分期、Ki-67、Bcl-2、缺氧诱导因子-1α（HIF-1α）、细胞周期蛋白D1与代谢肿瘤体积（MTV）、总病灶糖酵解（TLG）、通过氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG PET/CT）测量的最大标准化摄取值（SUV）之间的相关性。
本研究纳入了在我们三级医疗中心耳鼻喉科诊断并治疗的25例连续喉癌患者（2例女性，23例男性）。所有病例均接受了F FDG PET/CT检查，并计算了SUV、平均标准化摄取值、MTV和TLG值。进行了肿瘤分期，并对Ki-67、Bcl-2、HIF-1α和细胞周期蛋白D1进行了免疫组织化学染色。
8例（32%）患者为声门型喉癌，6例（24%）为声门上型喉癌，11例（44%）为跨声门型喉癌。细胞周期蛋白D1与MTV（r = 0.45，P = 0.03）、TLG（r = 0.492，P = 0.01）和T分期（r = 0.483，P = 0.02）显著相关。Bcl-2与SUV（r = -0.41，P = 0.05）和肿瘤分期（r = -0.442，P = 0.03）显著相关。MTV和TLG与淋巴结分期显著相关（r = 0.422，P = 0.04，r = 0.419，P = 0.04），而TLG（r = 0.403，P = 0.05）和SUV（r = 0.440，P = 0.03）与肿瘤分期相关。
我们的结果表明，细胞周期蛋白D1和Bcl-2等生物标志物与F-FDG PET/CT中的MTV、TLG和SUV等指标相关。对生物标志物和源自F-FDG PET/CT的影像数据进行综合评估，对于喉癌患者的分期和适当管理非常重要。
