Cantor Erika, Méndez Fabián, Rivera Carlos, Castillo Andrés, Martínez-Blanco Alexander
Research Institute, Centro Médico Imbanaco, Cali, Colombia,
School of Public Health, GESP Group, Universidad del Valle, Cali, Colombia.
Clin Ophthalmol. 2018 Aug 23;12:1511-1517. doi: 10.2147/OPTH.S165747. eCollection 2018.
The aim of the study was to evaluate the relationship between blood pressure (BP), ocular perfusion pressure (OPP) and occurrence of primary open-angle glaucoma (POAG) among patients with systemic hypertension.
A cross-sectional study of hypertensive patients was conducted in six cities in Colombia. The participants underwent a complete ophthalmological examination. The intraocular pressure measurement was obtained by Goldmann tonometry. The diagnosis of glaucoma was confirmed by visual field and optic nerve photos. Interviews and questionnaires were used to evaluate participants' lifestyle and other health conditions. A multinomial logistic regression was used to assess the relationship between BP, OPP and presence of suspected or confirmed POAG.
A total of 1,272 individuals were included in this study; 131 (10.3%) were diagnosed with suspected glaucoma and 65 (5.1%) with confirmed glaucoma. High values of diastolic BP (>90 mmHg) and low values of OPP (<40 mmHg) were associated to an increased risk of confirmed POAG. The type of antihypertensive treatment did not modify these relationships.
This study suggests that there is a close relationship between OPP and confirmed glaucoma in hypertensive patients, providing further evidence of the vascular mechanism in glaucoma pathogenesis.
本研究旨在评估系统性高血压患者的血压（BP）、眼灌注压（OPP）与原发性开角型青光眼（POAG）发生之间的关系。
在哥伦比亚的六个城市对高血压患者进行了一项横断面研究。参与者接受了全面的眼科检查。通过Goldmann眼压测量法获得眼压测量值。青光眼的诊断通过视野检查和视神经照片得以确认。采用访谈和问卷来评估参与者的生活方式及其他健康状况。运用多项逻辑回归来评估BP、OPP与疑似或确诊POAG之间的关系。
本研究共纳入1272名个体；131名（10.3%）被诊断为疑似青光眼，65名（5.1%）被确诊为青光眼。舒张压高值（>90 mmHg）和OPP低值（<40 mmHg）与确诊POAG风险增加相关。抗高血压治疗类型并未改变这些关系。
本研究表明高血压患者的OPP与确诊青光眼之间存在密切关系，为青光眼发病机制中的血管机制提供了进一步证据。
