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体位性直立性心动过速综合征患者的近红外光谱肌肉血氧测定法

Near-infrared spectroscopy muscle oximetry of patients with postural orthostatic tachycardia syndrome.

作者信息

Kadamati Parvathi, Sugar Jeffrey J, Quirk Brendan J, Mehrvar Shima, Chelimsky Gisela G, Whelan Harry T, Chelimsky Thomas C, Ranji Mahsa

机构信息

Biophotonics Laboratory, University of Wisconsin Milwaukee, Department of Electrical Engineering and Computer Science, 3200 N Cramer St., Milwaukee, WI 53211, USA.

Medical College of Wisconsin, Department of Neurology, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA.

出版信息

J Innov Opt Health Sci. 2018 Sep;11(6). doi: 10.1142/S1793545818500268. Epub 2018 Aug 13.

DOI:10.1142/S1793545818500268
PMID:30197684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6124683/
Abstract

Postural orthostatic tachycardia syndrome (POTS) is a disabling condition characterized by orthostatic intolerance with tachycardia in the absence of drop-in blood pressure. A custom-built near-infrared spectroscopy device (NIRS) is applied to monitor the muscle oxygenation, noninvasively in patients undergoing incremental head-up tilt table (HUT). Subjects (6 POTS patients and 6 healthy controls) underwent 30 mins of 70°on a HUT. The results showed a significant difference in deoxyhemoglobin (Hb), change-in-oxygenation (ΔOxy) and blood volume (ΔBV) between patients and healthy controls. However, oxyhemoglobin (HbO) showed a significantly faster rate of change in the healthy controls during the first 10 mins of the tilt and during the recovery. This NIRS muscle oximetry tool provides quantitative measurements of blood oxygenation monitoring in diseases such as POTS.

摘要

体位性直立性心动过速综合征（POTS）是一种致残性疾病，其特征为直立不耐受伴心动过速，且无血压下降。一种定制的近红外光谱设备（NIRS）被用于在进行递增式头高位倾斜试验（HUT）的患者中无创监测肌肉氧合情况。受试者（6例POTS患者和6名健康对照者）在HUT上进行了30分钟70°的倾斜试验。结果显示，患者与健康对照者之间的脱氧血红蛋白（Hb）、氧合变化（ΔOxy）和血容量（ΔBV）存在显著差异。然而，在倾斜试验的前10分钟以及恢复过程中，健康对照者的氧合血红蛋白（HbO）变化速率明显更快。这种NIRS肌肉血氧测定工具可为POTS等疾病的血液氧合监测提供定量测量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/6124683/cdeecf5ad485/nihms-985837-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/6124683/f8248df2923e/nihms-985837-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/6124683/f8248df2923e/nihms-985837-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/6124683/ae86bc853bbd/nihms-985837-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/6124683/28ee4194db12/nihms-985837-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/6124683/ac4d205b8e6e/nihms-985837-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/6124683/7d110db9f692/nihms-985837-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a00/6124683/cdeecf5ad485/nihms-985837-f0006.jpg

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