Fentiman I S, Fagg N, Millis R R, Hayward J L
Eur J Surg Oncol. 1986 Sep;12(3):261-6.
Ninety-seven patients with in situ ductal carcinoma (DCIS) of the breast have been reviewed. The commonest presenting feature was a breast lump, and residual carcinoma was found in the mastectomy specimen in 63% of patients. Furthermore, 13 cases had evidence of infiltrating carcinoma when the mastectomy specimen was examined. Thus excision alone would have left residual in situ or infiltrating carcinoma in two-thirds of the cases. A wide excision, by removing local residual disease, would still have left multifocal disease in one-third of cases. Studies need to be conducted to determine whether conservative treatment of DCIS can yield results which are as good as those following total mastectomy.
对97例乳腺导管原位癌（DCIS）患者进行了回顾性研究。最常见的临床表现是乳腺肿块，63%的患者在乳房切除标本中发现残留癌。此外，在检查乳房切除标本时，有13例存在浸润性癌的证据。因此，仅行切除手术会使三分之二的病例残留原位癌或浸润性癌。广泛切除虽然能去除局部残留病灶，但仍会使三分之一的病例存在多灶性病变。需要开展研究来确定对DCIS进行保守治疗是否能取得与全乳房切除相当的效果。
