Manukhin B N, Ledneva I P
Fiziol Zh SSSR Im I M Sechenova. 1986 Aug;72(8):1125-30.
A study performed on the isolated section of the rat small intestine has shown that at a slow increase in the concentration of the specific alpha-adrenomimetic phenylephrine in the incubation medium 1.0 X 10(-8) M/sec) adrenoreceptors pass into a state of desensitization without excitation, and no reaction takes place. At 2.5 X 10(-8)-10 X 10(-8) M/sec the reaction develops depending on the rate of phenylephrine introduction and is stabilized at 5.5-5.8 X 10(-6) M. Apparently, under these conditions an equilibrium is set up between activation and desensitization of adrenoreceptors. The role of desensitization of alpha-adrenoreceptors in the regulation of adrenergic reaction is discussed.
对大鼠小肠离体段进行的一项研究表明，在孵育培养基中特异性α-肾上腺素能拟似剂去氧肾上腺素浓度缓慢增加时（1.0×10⁻⁸M/秒），肾上腺素能受体进入脱敏状态而无兴奋，且无反应发生。在2.5×10⁻⁸ - 10×10⁻⁸M/秒时，反应根据去氧肾上腺素引入的速率发展，并在5.5 - 5.8×10⁻⁶M时稳定下来。显然，在这些条件下，肾上腺素能受体的激活与脱敏之间建立了平衡。讨论了α-肾上腺素能受体脱敏在肾上腺素能反应调节中的作用。
