用于标记和成像表达基质金属蛋白酶细胞的量子点基探针。
Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases.
作者信息
Benito-Alifonso David, Richichi Barbara, Baldoneschi Veronica, Berry Monica, Fragai Marco, Salerno Gianluca, Galan M Carmen, Nativi Cristina
机构信息
School of Chemistry, University of Bristol, Cantock's Close, BS8 1TS Bristol, U.K.
Department of Chemistry, University of Florence, via della Lastruccia, 3-13, Sesto Fiorentino, Florence 50019, Italy.
出版信息
ACS Omega. 2018 Aug 31;3(8):9822-9826. doi: 10.1021/acsomega.8b00633. Epub 2018 Aug 23.
The practical synthesis of novel multivalent fluorescent quantum-dot-based probes to target cellular matrix metalloproteinases (MMPs) (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not.
报道了用于靶向细胞基质金属蛋白酶（MT-MMPs）的新型多价荧光量子点基探针的实际合成方法。我们表明，这些用纳摩尔水溶性MMP抑制剂修饰的探针可用于优先标记已知表达MMPs的癌细胞表面，而在不表达的细胞上未观察到结合。
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