三分钟合成 sp 纳米晶碳点作为无毒荧光载药平台用于细胞内递送。
Three-minute synthesis of sp nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery.
机构信息
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK.
出版信息
Nanoscale. 2016 Nov 10;8(44):18630-18634. doi: 10.1039/c6nr07336k.
A one-pot, three-minute, gram-scale synthesis of novel sp-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.
一种由简单廉价的糖原料一步、三分钟、克级规模合成新型 sp 纳米晶、水溶、荧光碳点（FCDs）的方法。机理研究表明，NH-FCD 的形成是通过糖半缩醛和胺之间的反应生成的关键亚胺中间体进行的。此外，我们成功地证明了乳糖功能化 FCDots（Lac-FCDots）作为无毒荧光细胞内递药载体的应用。
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