钯-锌配合物的可见光吸收实现光诱导钯催化的根岸交叉偶联反应
Photoinduced Palladium-Catalyzed Negishi Cross-Couplings Enabled by the Visible-Light Absorption of Palladium-Zinc Complexes.
作者信息
Abdiaj Irini, Huck Lena, Mateo José Miguel, de la Hoz Antonio, Gomez M Victoria, Díaz-Ortiz Angel, Alcázar Jesús
机构信息
Discovery Sciences, Janssen Research and Development, Janssen-Cilag, S.A., Jarama 75A, 45007, Toledo, Spain.
Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Av. Camilo José Cela 10, 13071, Ciudad Real, Spain.
出版信息
Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13231-13236. doi: 10.1002/anie.201808654. Epub 2018 Sep 10.
A visible-light-induced Negishi cross-coupling is enabled by the activation of a Pd -Zn complex. With this photocatalytic method, the scope of deactivated aryl halides that can be employed in the Negishi coupling was significantly expanded. NMR experiments conducted in the presence and absence of light confirmed that the formation of the palladium-zinc complex is key for accelerating the oxidative addition step.
钯 - 锌配合物的活化实现了可见光诱导的根岸交叉偶联反应。通过这种光催化方法，可用于根岸偶联反应的钝化芳基卤化物的范围得到了显著扩展。在有光和无光条件下进行的核磁共振实验证实，钯 - 锌配合物的形成是加速氧化加成步骤的关键。
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