• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

连续流动合成助力反应发现。

Continuous flow synthesis enabling reaction discovery.

作者信息

Alfano Antonella Ilenia, García-Lacuna Jorge, Griffiths Oliver M, Ley Steven V, Baumann Marcus

机构信息

School of Chemistry, University College Dublin, Science Centre South Belfield Dublin 4 Ireland

Yusuf Hamied Department of Chemistry, University of Cambridge Lensfield Road CB2 1EW Cambridge UK

出版信息

Chem Sci. 2024 Feb 28;15(13):4618-4630. doi: 10.1039/d3sc06808k. eCollection 2024 Mar 27.

DOI:10.1039/d3sc06808k
PMID:38550700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10967013/
Abstract

This article defines the role that continuous flow chemistry can have in new reaction discovery, thereby creating molecular assembly opportunities beyond our current capabilities. Most notably the focus is based upon photochemical, electrochemical and temperature sensitive processes where continuous flow methods and machine assisted processing can have significant impact on chemical reactivity patterns. These flow chemical platforms are ideally placed to exploit future innovation in data acquisition, feed-back and control through artificial intelligence (AI) and machine learning (ML) techniques.

摘要

本文定义了连续流动化学在新反应发现中所能发挥的作用,从而创造出超出我们当前能力的分子组装机会。最值得注意的是,重点基于光化学、电化学和温度敏感过程,在这些过程中,连续流动方法和机器辅助处理会对化学反应模式产生重大影响。这些流动化学平台非常适合通过人工智能(AI)和机器学习(ML)技术来利用数据采集、反馈和控制方面的未来创新。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64f3/10967013/6e858382bc42/d3sc06808k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64f3/10967013/6e858382bc42/d3sc06808k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64f3/10967013/6e858382bc42/d3sc06808k-s1.jpg

相似文献

1
Continuous flow synthesis enabling reaction discovery.连续流动合成助力反应发现。
Chem Sci. 2024 Feb 28;15(13):4618-4630. doi: 10.1039/d3sc06808k. eCollection 2024 Mar 27.
2
Artificial Intelligence and Machine Learning in Pharmacological Research: Bridging the Gap Between Data and Drug Discovery.药理学研究中的人工智能与机器学习:弥合数据与药物发现之间的差距
Cureus. 2023 Aug 30;15(8):e44359. doi: 10.7759/cureus.44359. eCollection 2023 Aug.
3
Exploring the artificial intelligence and machine learning models in the context of drug design difficulties and future potential for the pharmaceutical sectors.探索人工智能和机器学习模型在药物设计难题方面的应用及对制药行业未来的潜在影响。
Methods. 2023 Nov;219:82-94. doi: 10.1016/j.ymeth.2023.09.010. Epub 2023 Sep 29.
4
Artificial intelligence and machine learning applications in biopharmaceutical manufacturing.人工智能和机器学习在生物制药制造中的应用。
Trends Biotechnol. 2023 Apr;41(4):497-510. doi: 10.1016/j.tibtech.2022.08.007. Epub 2022 Sep 15.
5
Revolutionizing Medicinal Chemistry: The Application of Artificial Intelligence (AI) in Early Drug Discovery.变革药物化学:人工智能在早期药物发现中的应用。
Pharmaceuticals (Basel). 2023 Sep 6;16(9):1259. doi: 10.3390/ph16091259.
6
Integrating Artificial Intelligence for Drug Discovery in the Context of Revolutionizing Drug Delivery.在药物递送变革的背景下整合人工智能用于药物发现。
Life (Basel). 2024 Feb 7;14(2):233. doi: 10.3390/life14020233.
7
Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery.人工智能在计算机辅助药物发现中的概念。
Chem Rev. 2019 Sep 25;119(18):10520-10594. doi: 10.1021/acs.chemrev.8b00728. Epub 2019 Jul 11.
8
New avenues in artificial-intelligence-assisted drug discovery.人工智能辅助药物发现的新途径。
Drug Discov Today. 2023 Apr;28(4):103516. doi: 10.1016/j.drudis.2023.103516. Epub 2023 Feb 2.
9
Artificial Intelligence and Machine Learning Technology Driven Modern Drug Discovery and Development.人工智能和机器学习技术推动现代药物发现和开发。
Int J Mol Sci. 2023 Jan 19;24(3):2026. doi: 10.3390/ijms24032026.
10
The machine learning life cycle and the cloud: implications for drug discovery.机器学习生命周期与云:对药物发现的影响。
Expert Opin Drug Discov. 2021 Sep;16(9):1071-1079. doi: 10.1080/17460441.2021.1932812. Epub 2021 May 31.

引用本文的文献

1
[2+2]-Photocycloadditions of 1,4-Naphthoquinone Under Batch and Continuous-Flow Conditions.1,4-萘醌在间歇和连续流动条件下的[2+2]光环加成反应
Molecules. 2024 Dec 15;29(24):5920. doi: 10.3390/molecules29245920.
2
Integrating continuous flow reaction and work-up: chiral amine resolution, separation and purification using a novel coalescing filter system.整合连续流反应与后处理:使用新型聚结过滤系统进行手性胺拆分、分离及纯化
React Chem Eng. 2024 Nov 13;10(2):392-397. doi: 10.1039/d4re00442f. eCollection 2025 Jan 28.
3
Structurally Diverse Nitrogen-Rich Scaffolds via Continuous Photo-Click Reactions.

本文引用的文献

1
Electrosynthesis of Spiro-indolenines via Dearomative Arylation of Indoles in Batch and Continuous Flow.通过批次和连续流中吲哚的去芳构化芳基化反应电合成螺吲哚啉。
Org Lett. 2023 Oct 13;25(40):7451-7456. doi: 10.1021/acs.orglett.3c03149. Epub 2023 Oct 4.
2
Synthesis of Highly Reactive Ketenimines via Photochemical Rearrangement of Isoxazoles.通过异恶唑的光化学重排合成高反应性的烯酮亚胺。
Org Lett. 2023 Sep 8;25(35):6593-6597. doi: 10.1021/acs.orglett.3c02556. Epub 2023 Aug 24.
3
Efficient C(sp )-H Carbonylation of Light and Heavy Hydrocarbons with Carbon Monoxide via Hydrogen Atom Transfer Photocatalysis in Flow.
通过连续光点击反应构建结构多样的富氮骨架
Org Lett. 2024 Dec 13;26(49):10559-10563. doi: 10.1021/acs.orglett.4c03953. Epub 2024 Nov 26.
4
Direct Photochemical Synthesis of Substituted Benzo[]fluorenes.取代苯并[]芴的直接光化学合成
Org Lett. 2024 Dec 6;26(48):10364-10368. doi: 10.1021/acs.orglett.4c03978. Epub 2024 Nov 24.
5
Visible-light-driven synthesis of alkenyl thiocyanates: novel building blocks for assembly of diverse sulfur-containing molecules.可见光驱动的硫氰酸烯基酯的合成:用于组装多种含硫分子的新型构建模块。
Chem Sci. 2024 Oct 23;15(45):19077-83. doi: 10.1039/d4sc06550f.
6
New Opportunities for Organic Synthesis with Superheated Flow Chemistry.超热流动化学助力有机合成的新机遇
Acc Chem Res. 2024 Aug 6;57(15):2207-2218. doi: 10.1021/acs.accounts.4c00340. Epub 2024 Jul 23.
通过流动体系中的氢原子转移光催化实现轻烃和重烃与一氧化碳的高效C(sp )-H羰基化反应
Angew Chem Int Ed Engl. 2023 Sep 4;62(36):e202308563. doi: 10.1002/anie.202308563. Epub 2023 Jul 27.
4
A field guide to flow chemistry for synthetic organic chemists.合成有机化学家的流动化学实地指南。
Chem Sci. 2023 Mar 15;14(16):4230-4247. doi: 10.1039/d3sc00992k. eCollection 2023 Apr 26.
5
Organic reactivity from mechanism to machine learning.从机理到机器学习的有机反应活性
Nat Rev Chem. 2021 Apr;5(4):240-255. doi: 10.1038/s41570-021-00260-x. Epub 2021 Mar 16.
6
Carbene-controlled regioselectivity in photochemical cascades.光化学级联反应中卡宾控制的区域选择性
Org Biomol Chem. 2023 Apr 5;21(14):2930-2934. doi: 10.1039/d3ob00122a.
7
New Additions to the Arsenal of Biocatalysts for Noncanonical Amino Acid Synthesis.用于非标准氨基酸合成的生物催化剂库的新成员
Curr Opin Green Sustain Chem. 2022 Dec;38. doi: 10.1016/j.cogsc.2022.100701. Epub 2022 Sep 15.
8
Guided discovery of chemical reaction pathways with imposed activation.通过施加活化作用来引导化学反应途径的发现。
Chem Sci. 2022 Nov 10;13(46):13857-13871. doi: 10.1039/d2sc05135d. eCollection 2022 Nov 30.
9
Taming Highly Unstable Radical Anions and 1,4-Organodilithiums by Flow Microreactors: Controlled Reductive Dimerization of Styrenes.利用流动微反应器驯服高度不稳定的自由基阴离子和1,4 - 有机二锂:苯乙烯的可控还原二聚反应
JACS Au. 2022 Oct 31;2(11):2514-2521. doi: 10.1021/jacsau.2c00375. eCollection 2022 Nov 28.
10
Continuous-Flow Divergent Lithiation of 2,3-Dihalopyridines: Deprotolithiation versus Halogen Dance.2,3-二卤代吡啶的连续流动发散锂化反应:脱锂化与卤原子舞蹈。
Chemistry. 2022 Dec 20;28(71):e202202286. doi: 10.1002/chem.202202286. Epub 2022 Oct 31.