Cullman Chemoprotection Center.
Department of International Health, Center for Human Nutrition.
Curr Opin Clin Nutr Metab Care. 2018 Nov;21(6):451-457. doi: 10.1097/MCO.0000000000000511.
Neurologic disorders have varied pathophysiology, yet many of them appear to have core molecular pathways that are aberrant. We review the evidence that a dietary component may have utility in ameliorating or preventing at least some of them.
The weight of evidence supporting prescriptive dietary recommendations to promote or enhance healthspan has been building for decades. Cruciferous vegetables are a key part of the arsenal of nutrition-based approaches for reducing the burden of chronic disease. Much new evidence suggests that neurological disorders are among the potential targets for this approach. This evidence includes at least nine clinical studies of neurodevelopmental conditions like autism spectrum disorder and schizophrenia, and there are a great many studies in animal model systems, of neurodegenerative disorders like Alzheimer's and Parkinson's diseases. This review highlights the most bioactive and most well-studied compounds from crucifers - the isothiocyanates, in particular sulforaphane.
There is great promise for the regular use of cruciferous vegetables or supplements containing standardized levels of bioactives in the treatment and prevention of neurologic disorders. Many clinical and animal studies are underway, and the evidence is building to support this strategy.
神经紊乱具有不同的病理生理学机制，但其中许多似乎存在异常的核心分子途径。我们综述了饮食成分可能有助于改善或预防其中至少一些疾病的证据。
几十年来，支持规定饮食建议以促进或延长健康寿命的证据越来越多。十字花科蔬菜是基于营养方法减轻慢性疾病负担的重要组成部分。许多新的证据表明，神经紊乱是这种方法的潜在目标之一。这些证据包括至少 9 项针对自闭症谱系障碍和精神分裂症等神经发育障碍的临床研究，以及大量针对阿尔茨海默病和帕金森病等神经退行性疾病的动物模型系统研究。本综述重点介绍了十字花科植物中最具生物活性和研究最多的化合物——异硫氰酸酯，特别是萝卜硫素。
经常食用十字花科蔬菜或含有标准化生物活性物质的补充剂，有望治疗和预防神经紊乱。许多临床和动物研究正在进行中，支持这种策略的证据也在不断增加。
