Department of Psychology, University of Houston, United States.
Syracuse University, Department of Psychology, Syracuse, NY, United States.
Addict Behav. 2019 Jan;88:157-162. doi: 10.1016/j.addbeh.2018.08.039. Epub 2018 Sep 1.
Persons living with HIV/AIDS (PLWHA) report high rates of clinically significant pain that is associated with several negative outcomes, including higher CD4 T-cell count, poor medication adherence, and substance use and misuse. Importantly, PLWHA also report elevated rates of both opioid and tobacco use, and these elevated rates have often been associated with increased pain experience. Although research suggests that negative affective responses to pain may be uniquely associated with substance misuse among individuals in the general population, little work has examined these relations among PLWHA. The current study examined negative emotions in response to pain as a predictor of current opioid misuse, future opioid misuse, and perceived smoking-pain relationships among 66 (M = 51.26, SD = 8.00, 60.6% male) HIV+ adults with co-occurring pain. Results indicated that negative emotions in response to pain uniquely predicted each of the substance use outcomes, with clinically significant effect sizes that may be characterized as medium in magnitude. Overall, these findings suggest that negative affective responses to pain may play a role in prescription opioid misuse and smoking among PLWHA. These findings may inform the development of tailored interventions for PLWHA smokers who are prescribed opioid pain medications.
HIV/AIDS 感染者（PLWHA）报告称，他们有很高比例的临床显著疼痛，这与多种负面结果有关，包括 CD4 细胞计数升高、药物治疗依从性差、物质使用和滥用。重要的是，PLWHA 也报告了阿片类药物和烟草使用的比例升高，而这些升高的比例往往与疼痛体验增加有关。尽管研究表明，对疼痛的负面情感反应可能与一般人群中物质滥用的独特相关，但在 PLWHA 中很少有研究检查这些关系。本研究调查了对疼痛的负面情绪作为当前阿片类药物滥用、未来阿片类药物滥用以及 66 名（M=51.26，SD=8.00，60.6%为男性）共病疼痛的 HIV+ 成年人中感知吸烟-疼痛关系的预测因子。结果表明，对疼痛的负面情绪反应可单独预测每种物质使用结果，其临床显著效应大小可被描述为中等强度。总的来说，这些发现表明，对疼痛的负面情感反应可能在 PLWHA 中处方类阿片药物滥用和吸烟中起作用。这些发现可能为制定针对 PLWHA 吸烟者的量身定制干预措施提供信息，这些吸烟者开了阿片类止痛药。
