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一项针对痴呆症患者的认知刺激疗法项目的疗效

Efficacy of a cognitive stimulation therapy programme for people with dementia.

作者信息

Coen Robert F, Flynn Bronagh, Rigney Edel, O'Connor Elaine, Fitzgerald Liza, Murray Ciaran, Dunleavy Catherine, McDonald Mindy, Delaney Deirdre, Merriman Niamh, Edgeworth Jennifer

机构信息

Mercer's Institute For Research On Ageing,St James's Hospital,Dublin 8.

Occupational Therapy Dept,St James's Hospital,Dublin 8.

出版信息

Ir J Psychol Med. 2011 Sep;28(3):145-147. doi: 10.1017/S0790966700012131.

Abstract

OBJECTIVES

Cognitive stimulation therapy (CST) has been shown to produce improvements in cognition and quality of life which compare favourably with trials of cholinesterase inhibitors. The aim of the present study was to evaluate the efficacy of CST, replicating the methods of Spector et al in the British Journal of Psychiatry in 2003 in a smaller sample using a control group engaged in routine activities.

METHODS

Eligible participants (mild to moderate dementia; MMSE range 10-23) were randomised to CST group or control conditions. Pre- and post-intervention testing was undertaken by assessors who were blind to condition. Measures included MMSE, CDR (sum of boxes), ADAS-cog, RAID (anxiety), abbreviated GDS (depression), QoL-AD, and the CAPE Behaviour Rating Scale (BRS). Analysis was by non-parametric statistics. Occupational therapists facilitated two sessions per week for seven weeks in two long-term care facilities and the same programme was run by the activity co-ordinator in a nursing home unit.

RESULTS

Fourteen CST and 13 control participants completed the study. Between group difference scores analysis showed that the CST group improved compared to controls on MMSE (Mann-Whitney U = 32, p = 0.013) and on the QoL-AD which just fell short of significant (U=51.5, p = 0.055). Qualitatively, therapists noted that CST participants demonstrated good interaction and enthusiasm in the group environment, with continuity and carryover between sessions.

CONCLUSIONS

Even though the sample sizes are small the current study is consistent with the Spector et al's findings in 2003 of beneficial effects in people with dementia following CST. The programme is recommended as an intervention for people with mild to moderate dementia.

摘要

目的

认知刺激疗法(CST)已被证明能改善认知和生活质量,与胆碱酯酶抑制剂试验相比效果良好。本研究的目的是评估CST的疗效,采用2003年《英国精神病学杂志》中Spector等人的方法,在一个较小样本中使用参与日常活动的对照组。

方法

符合条件的参与者(轻度至中度痴呆;MMSE范围为10 - 23)被随机分配到CST组或对照条件组。干预前后的测试由对分组情况不知情的评估人员进行。测量指标包括MMSE、CDR(方框总和)、ADAS - cog、RAID(焦虑)、简化版GDS(抑郁)、QoL - AD和CAPE行为评定量表(BRS)。分析采用非参数统计方法。职业治疗师在两个长期护理机构每周进行两次为期七周的治疗,疗养院单元的活动协调员执行相同的方案。

结果

14名接受CST治疗的参与者和13名对照组参与者完成了研究。组间差异分数分析表明,CST组在MMSE(曼 - 惠特尼U = 32,p = 0.013)和QoL - AD方面与对照组相比有所改善,QoL - AD接近显著水平(U = 51.5,p = 0.055)。定性地说,治疗师指出接受CST治疗的参与者在小组环境中表现出良好的互动和热情,各次治疗之间具有连续性和延续性。

结论

尽管样本量较小,但当前研究与Spector等人在2003年发现的CST对痴呆患者有益的结果一致。该方案推荐作为轻度至中度痴呆患者的一种干预措施。

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