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验证认知刺激疗法(CST)在葡萄牙痴呆患者中的应用。

Validation of the cognitive stimulation therapy (CST) program for people with dementia in Portugal.

机构信息

Health Sciences Institute, Portuguese Catholic University, Lisboa, Portugal.

Interdisciplinary Health Research Center, Catholic University of Portugal, Lisboa, Portugal.

出版信息

Aging Ment Health. 2021 Jun;25(6):1019-1028. doi: 10.1080/13607863.2020.1836473. Epub 2020 Oct 22.

Abstract

BACKGROUND

Cognitive Stimulation Therapy (CST) is considered a gold-standard, evidence-based and cost-effective approach to improve cognitive function and quality of life of people with mild to moderate dementia.

AIMS

To validate CST for the Portuguese population and test its effectiveness.

METHODS

A single-blind, multi-center, randomized controlled trial recruited 112 older people with dementia. The primary outcome measure was cognition and secondary measures were quality of life, communication, autonomy, anxiety, depression, and global functioning. We also explored whether CST benefits people differently according to context, gender and level of cognitive reserve.

RESULTS

Fifty-five people were randomized to the intervention and 57 to the control group. In the post-test, the intervention group significantly improved relative to controls in cognition (ADAS-Cog,  = 0.013), communication (HCS,  = 0.045), behaviour (CAPE-BRS,  = 0.017) and in global dementia rating (CDR,  = 0.008). Quality of life, depression and anxiety had no significant differences. The estimated number needed to treat was four for one to benefit a cognitive improvement (ADAS-Cog).

CONCLUSIONS

Group CST is valid for the Portuguese population with benefits for people with mild to moderate dementia.

摘要

背景

认知刺激疗法(CST)被认为是改善轻度至中度痴呆患者认知功能和生活质量的金标准、基于证据和具有成本效益的方法。

目的

验证 CST 在葡萄牙人群中的有效性。

方法

一项单盲、多中心、随机对照试验招募了 112 名老年痴呆症患者。主要结局指标是认知,次要结局指标是生活质量、沟通、自主性、焦虑、抑郁和整体功能。我们还探讨了 CST 是否根据环境、性别和认知储备水平对不同人群产生不同的益处。

结果

55 人被随机分配到干预组,57 人分配到对照组。在 post-test 中,与对照组相比,干预组在认知(ADAS-Cog, = 0.013)、沟通(HCS, = 0.045)、行为(CAPE-BRS, = 0.017)和整体痴呆评定(CDR, = 0.008)方面有显著改善。生活质量、抑郁和焦虑没有显著差异。估计需要治疗的人数为 4 人,以获得认知改善(ADAS-Cog)。

结论

团体 CST 在葡萄牙人群中是有效的,对轻度至中度痴呆患者有益。

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