Sachs G S, Pollack M H, Brotman A W, Farhadi A M, Gelenberg A J
J Clin Psychiatry. 1986 Oct;47(10):508-10.
Three patients with major depression who were pretreated with yohimbine 10 mg p.o. showed a dramatic response without major adverse effects following two electroconvulsive treatments (ECT). The hypothesis that the alpha 2-adrenergic antagonist yohimbine accelerates ECT-induced postsynaptic beta-adrenergic receptor down-regulation is discussed.