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正常妊娠和妊娠期糖尿病妊娠的母体外周血浆与脐静脉血浆的比较蛋白质组学分析

Comparative proteomic analysis of maternal peripheral plasma and umbilical venous plasma from normal and gestational diabetes mellitus pregnancies.

作者信息

Liao Yun, Xu Gu-Feng, Jiang Ying, Zhu Hong, Sun Li-Juan, Peng Rong, Luo Qiong

机构信息

Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Medicine (Baltimore). 2018 Sep;97(36):e12232. doi: 10.1097/MD.0000000000012232.

DOI:10.1097/MD.0000000000012232
PMID:30200149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6133416/
Abstract

Gestational diabetes mellitus (GDM) increases many health risks in offspring. The study aims to investigate the underlying mechanism in fetal risk of GDM.We collected maternal peripheral plasma and umbilical venous plasma samples from 4 GDM and 4 control patients during their delivery at a university-based women's hospital. An isobaric tag for relative and absolute quantitation-labeled proteomics analysis was performed. The enzyme-linked immunosorbent assay was used to confirm the change of cholesteryl ester transfer protein (CETP). Bioinformatic analysis was performed with Ingenuity Pathway Analysis (IPA) software package.We identified 19 up-regulated proteins and 15 down-regulated proteins in GDM peripheral plasma, 29 up-regulated proteins and 69 down-regulated proteins in GDM umbilical venous plasma. CETP concentration was significantly lower in both GDM peripheral plasma and umbilical venous plasma. Upstream regulator analysis predicted follicle-stimulating hormone (FSH) as the activated regulator of differentially expressed proteins.The protein profiles in both GDM peripheral plasma and umbilical venous plasma between normal and GDM patients were significantly different. The results indicated that CETP and FSH might associates with health problem of GDM offspring.

摘要

妊娠期糖尿病（GDM）会增加后代的多种健康风险。本研究旨在探讨GDM胎儿风险的潜在机制。我们在一家大学附属医院收集了4例GDM患者和4例对照患者分娩时的母体外周血血浆和脐静脉血浆样本。进行了相对和绝对定量标记的蛋白质组学分析。采用酶联免疫吸附测定法确认胆固醇酯转运蛋白（CETP）的变化。使用Ingenuity Pathway Analysis（IPA）软件包进行生物信息学分析。我们在GDM外周血血浆中鉴定出19种上调蛋白和15种下调蛋白，在GDM脐静脉血浆中鉴定出29种上调蛋白和69种下调蛋白。GDM外周血血浆和脐静脉血浆中的CETP浓度均显著降低。上游调节因子分析预测促卵泡激素（FSH）为差异表达蛋白的激活调节因子。正常患者与GDM患者的GDM外周血血浆和脐静脉血浆中的蛋白质谱均存在显著差异。结果表明，CETP和FSH可能与GDM后代的健康问题有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/b94c98fd042f/medi-97-e12232-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/39f75ce8bc8e/medi-97-e12232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/873eb34e8875/medi-97-e12232-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/92ce8a862f12/medi-97-e12232-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/b7871082f887/medi-97-e12232-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/b94c98fd042f/medi-97-e12232-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/39f75ce8bc8e/medi-97-e12232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/873eb34e8875/medi-97-e12232-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/92ce8a862f12/medi-97-e12232-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/b7871082f887/medi-97-e12232-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/131a/6133416/b94c98fd042f/medi-97-e12232-g009.jpg

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