College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Molecules. 2018 Aug 30;23(9):2188. doi: 10.3390/molecules23092188.
This study investigated the influence of extract (CAext) on intestinal microbiota composition of mice fed a high-fat diet (HFD). Kun Ming (KM) mice were fed either a normal chow diet or a HFD for six weeks. At the seventh week, HFD-fed mice were gavaged daily with saline, or a different dose of CAext for four weeks, respectively. Then, the composition of the gut microbiota was analyzed by high-throughput sequencing technology. Analysis of fecal microbial populations, grouped by phyla, showed significant increases of and , but a decrease of in all CAext-fed mice. Particularly, CAext gavage in a low dose or a medium dose caused a significant increase in the proportion of . These findings suggested that CAext can alter the gut microbiota composition of HFD-fed mice, and had a potential prebiotic effects on .
本研究旨在探讨 提取物（CAext）对高脂饮食（HFD）喂养小鼠肠道微生物组成的影响。昆明（KM）小鼠分别喂食正常饲料或 HFD 六周。在第七周，HFD 喂养的小鼠分别每天用生理盐水或不同剂量的 CAext 灌胃，持续四周。然后，通过高通量测序技术分析肠道微生物群的组成。通过门水平分析粪便微生物群，结果显示所有 CAext 喂养的小鼠中 和 的丰度显著增加，而 的丰度降低。特别是，低剂量或中剂量的 CAext 灌胃可显著增加 的比例。这些结果表明，CAext 可以改变 HFD 喂养小鼠的肠道微生物组成，并且对 具有潜在的益生元作用。
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