Laboratory of Cell and Molecular Biology, Institute of Vegetable Science, Zhejiang University, Hangzhou 310058, China.
Key Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Ministry of Agriculture, Hangzhou 310058, China.
Int J Mol Sci. 2018 Aug 31;19(9):2589. doi: 10.3390/ijms19092589.
Flower development is the core of higher-plant ontogenesis and is controlled by complex gene regulatory networks. Cys₂/His₂ zinc-finger proteins (C2H2-ZFPs) constitute one of the largest transcription factor families and are highly involved in transcriptional regulation of flowering induction, floral organ morphogenesis, and pollen and pistil maturation. Nevertheless, the molecular mechanism of C2H2-ZFPs has been gradually revealed only in recent years. During flowering induction, C2H2-ZFPs can modify the chromatin of , thereby providing additional insights into the quantification of transcriptional regulation caused by chromatin regulation. C2H2-ZFPs are involved in cell division and proliferation in floral organ development and are associated with hormonal regulation, thereby revealing how a flower is partitioned into four developmentally distinct whorls. The studies reviewed in this work integrate the information from the endogenous, hormonal, and environmental regulation of flower development. The structure of C2H2-ZFPs determines their function as transcriptional regulators. The findings indicate that C2H2-ZFPs play a crucial role in flower development. In this review, we summarize the current understanding of the structure, expression, and function of C2H2-ZFPs and discuss their molecular mechanism in flower development.
花的发育是高等植物个体发育的核心，受到复杂的基因调控网络的控制。Cys₂/His₂锌指蛋白（C2H2-ZFPs）构成最大的转录因子家族之一，高度参与开花诱导、花器官形态建成以及花粉和雌蕊成熟的转录调控。然而，近年来才逐渐揭示 C2H2-ZFPs 的分子机制。在开花诱导过程中，C2H2-ZFPs 可以修饰染色质，从而为染色质调控引起的转录调控的定量提供了更多的见解。C2H2-ZFPs 参与花器官发育中的细胞分裂和增殖，并与激素调控有关，从而揭示了一朵花是如何被分成四个在发育上有明显区别的轮。本综述整合了花发育的内源性、激素和环境调控的信息。C2H2-ZFPs 的结构决定了它们作为转录调节剂的功能。研究结果表明，C2H2-ZFPs 在花的发育中起着至关重要的作用。在这篇综述中，我们总结了目前对 C2H2-ZFPs 的结构、表达和功能的理解，并讨论了它们在花发育中的分子机制。
