Miura Natsuko, Ueda Mitsuyoshi
Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai 599-8531, Japan.
Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Cells. 2018 Aug 31;7(9):128. doi: 10.3390/cells7090128.
Development of proteome analysis of extracellular proteins has revealed that a wide variety of proteins, including fungal allergens are present outside the cell. These secreted allergens often do not contain known secretion signal sequences. Recent research progress shows that some fungal allergens are secreted by unconventional secretion pathways, including autophagy- and extracellular-vesicle-dependent pathways. However, secretion pathways remain unknown for the majority of extracellular proteins. This review summarizes recent data on unconventional protein secretion in and other fungi. Particularly, methods for evaluating unconventional protein secretion are proposed for fungal species, including , a popular model organism for investigating protein secretion pathways.
细胞外蛋白质组分析的发展表明，细胞外存在多种蛋白质，包括真菌过敏原。这些分泌的过敏原通常不包含已知的分泌信号序列。最近的研究进展表明，一些真菌过敏原是通过非常规分泌途径分泌的，包括自噬依赖性和细胞外囊泡依赖性途径。然而，大多数细胞外蛋白质的分泌途径仍然未知。本综述总结了关于丝状真菌和其他真菌中非常规蛋白质分泌的最新数据。特别是，针对丝状真菌提出了评估非常规蛋白质分泌的方法，丝状真菌是研究蛋白质分泌途径的常用模式生物。
