Zhang Yi-Guan, Tan Rui-Rong, Ren Si-Chong, Ma Xin, Yan Zhi-Xiang, Hua Hua, Yan Liang-Chun, Dai Ying, Zhao Jun-Ning
Sichuan Center for Translational Medicine of Traditional Chinese Medicine, Institute of Translational Pharmacology of Sichuan Academy of Chinese Medicine Sciences, State Key Laboratory of Quality Evaluation of Traditional Chinese Medicine, Sichuan Geoherbs System Engineering Technology Research Center of Chinese Medicine, Sichuan Provincial Key Laboratory of Quality Evaluation of Traditional Chinese Medicine and Innovative Chinese Medicine Research, Chengdu 610041, China.
Zhongguo Zhong Yao Za Zhi. 2018 Aug;43(16):3229-3234. doi: 10.19540/j.cnki.cjcmm.20180629.002.
For the basic research on the traditional Chinese medicine(TCM), objective syndrome of traditional Chinese medicine and evaluation criteria of traditional Chinese medicine compounds are hardly to break though. While, the modern immunology points out that the body is a counterbalance state and immune imbalance is the root of sickness. The thinking mode of treating diseases in traditional Chinese medicine is also "balance", considering disease is the result of bias which present the imbalance of "Yin counters Yang", "exterior counters interior", "cold counters heat" and "weak counters strong". The Chinese herbal compound formula preparation was applied on disease therapy based on theory of Chinese medicine, which was confirmed by long period clinical application. It is composed of multi-compounds and has the characteristic of multi-targeting. Integrative medicine has spawned pan-immunomics, and the evaluation of immune function (immune balance) has become an important basis for diagnosis and treatment models of integrative medicine. In addition, balance is the core idea of whole-systemic conception of traditional Chinese medicine. Therefore, we speculate that immune balance under pan-immunomic can bridge the traditional Chinese medicine and modern integrative medicine and is the important basis for objective syndrome of traditional Chinese medicine and evaluation criteria of traditional Chinese medicine compounds. According to the bridging theory, we attempt to utilize informatics and statistical methods to construct an evaluation system for pharmacodynamics of traditional Chinese medicine based on its moderate regulation and the balanced adjustment of immunity under pan-immunomic, which further reveal the scientific essence of the whole-systemic view of traditional Chinese medicine. This research brings out a new valuable strategy and provides a theoretical basis for accelerating the transformation of traditional Chinese medicine, especially the exploitation of Chinese herbal compound formula, and constructing the new drug innovation and review system for traditional Chinese medicine. Besides as a reference for traditional Chinese medicine objective syndrome and pharmacodynamics of traditional Chinese medicine compounds, the evaluation system can screen the immunity of sub-health population also. With the continuous accumulation of clinical sample and data, the evaluation system will be more accurate and intelligent.
对于中医药基础研究而言，中医客观证候及中药复方评价标准难以突破。而现代免疫学指出，人体处于一种平衡状态，免疫失衡是疾病的根源。中医的治病思维模式也是“平衡”，认为疾病是“阴阳失调”“表里失调”“寒热失调”“虚实失调”等失衡状态的体现。中药复方制剂依据中医理论应用于疾病治疗，经长期临床应用得以证实。它由多种化合物组成，具有多靶点特性。中西医结合催生了泛免疫组学，免疫功能（免疫平衡）评价已成为中西医结合诊疗模式的重要依据。此外，平衡是中医整体观念的核心思想。因此，我们推测泛免疫组学下的免疫平衡能够架起中医与现代中西医结合医学的桥梁，是中医客观证候及中药复方评价标准的重要依据。依据这一桥梁理论，我们尝试利用信息学和统计学方法，基于泛免疫组学下中药对免疫的适度调节和平衡调节构建中药药效评价体系，进一步揭示中医整体观的科学本质。本研究提出了一种新的有价值策略，为加速中医药现代化，特别是中药复方制剂的研发，构建中药新药创新与审评体系提供了理论依据。此外，该评价体系作为中医客观证候及中药复方药效学的参考，还可用于筛选亚健康人群的免疫状态。随着临床样本和数据的不断积累，评价体系将更加准确和智能化。
