Martino E, Mariotti S, Aghini-Lombardi F, Lenziardi M, Morabito S, Baschieri L, Pinchera A, Braverman L, Safran M
J Clin Endocrinol Metab. 1986 Nov;63(5):1233-6. doi: 10.1210/jcem-63-5-1233.
We studied the effect of potassium perchlorate (KClO4) in patients with hypothyroidism due to amiodarone. The short term administration of KClO4 to six such patients led to prompt restoration of euthyroidism, while the three untreated patients remained hypothyroid for 2-6 months. Since KClO4 inhibits thyroid iodide transport, thereby blocking further entrance of iodide into the thyroid and decreasing intrathyroidal iodide content, amiodarone-associated hypothyroidism is probably secondary to the inhibitory effect of excess intrathyroidal iodine on thyroid hormone synthesis.
我们研究了高氯酸钾（KClO4）对胺碘酮所致甲状腺功能减退患者的影响。对6例此类患者短期给予高氯酸钾后，甲状腺功能迅速恢复正常，而3例未治疗的患者甲状腺功能减退持续了2 - 6个月。由于高氯酸钾抑制甲状腺碘转运，从而阻止碘进一步进入甲状腺并降低甲状腺内碘含量，胺碘酮相关的甲状腺功能减退可能继发于甲状腺内过量碘对甲状腺激素合成的抑制作用。
