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一对异性恋伴侣中同时发生的肛门肛管癌。

Synchronous anal canal carcinoma in a heterosexual couple.

机构信息

Department of Radiation Oncology, Sunnybrook Health Sciences Centre T-Wing, University of Toronto, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada.

Division of Anatomic Pathology, Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, Canada.

出版信息

BMC Cancer. 2018 Sep 10;18(1):884. doi: 10.1186/s12885-018-4785-8.

DOI:10.1186/s12885-018-4785-8
PMID:30200930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6131756/
Abstract

BACKGROUND

Sexually transmitted Human Papilloma Virus (HPV) infection is a known risk factor for cancer of the anal canal in both men and women.

CASE PRESENTATION

We describe a report of synchronous carcinoma of the anal canal in a heterosexual couple. High risk type 16 HPV DNA was detected in both tumors.

CONCLUSION

Longstanding sexual partners may share risk of HPV-associated anal canal cancer.

摘要

背景

性传播人乳头瘤病毒（HPV）感染是男性和女性肛管癌的已知危险因素。

病例报告

我们描述了一对异性恋夫妇同时发生的肛管癌病例报告。在两个肿瘤中均检测到高危型 16 HPV DNA。

结论

长期的性伴侣可能具有 HPV 相关的肛管癌风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a760/6131756/0ba3fc7aa30a/12885_2018_4785_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a760/6131756/4af625d0a8e8/12885_2018_4785_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a760/6131756/0ba3fc7aa30a/12885_2018_4785_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a760/6131756/4af625d0a8e8/12885_2018_4785_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a760/6131756/0ba3fc7aa30a/12885_2018_4785_Fig2_HTML.jpg

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J Virol. 2018 May 29;92(12). doi: 10.1128/JVI.00017-18. Print 2018 Jun 15.
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Is there an increased risk of cancer among spouses of patients with an HPV-related cancer: A systematic review.人乳头瘤病毒相关癌症患者的配偶患癌风险是否增加：一项系统评价
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Anal Cancer Incidence in the United States, 1977-2011: Distinct Patterns by Histology and Behavior.1977 - 2011年美国肛管癌发病率：按组织学和行为划分的不同模式
Cancer Epidemiol Biomarkers Prev. 2015 Oct;24(10):1548-56. doi: 10.1158/1055-9965.EPI-15-0044. Epub 2015 Jul 29.
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Prevalence of and risk factors for anal human papillomavirus infection in men who have sex with women: a cross-national study.女性性伴侣男男性行为者肛门人乳头瘤病毒感染的流行率和危险因素：一项跨国研究。
J Infect Dis. 2010 May 15;201(10):1498-508. doi: 10.1086/652187.
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Immunosuppressive disorders and risk of anal squamous cell carcinoma: a nationwide cohort study in Denmark, 1978-2005.免疫抑制障碍与肛门鳞状细胞癌风险：丹麦 1978-2005 年全国队列研究。
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