Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
J Microbiol Immunol Infect. 2019 Apr;52(2):233-241. doi: 10.1016/j.jmii.2018.08.009. Epub 2018 Aug 30.
Human rhinovirus (HRV) can cause severe illnesses in hospitalized patients. However, there are no studies regarding the prevalence of HRV infection, particularly the recently identified HRV-C, in hospitalized patients reported from Taiwan.
Respiratory specimens collected from 487 hospitalized patients in designated wards between 2013 and 2014 in a medical center in northern Taiwan were retrospectively detected for HRV. Positive specimens were further determined for genotyping. Medical charts of the HRV-positive patients were reviewed retrospectively.
Totally, 76 patients (15.6%) were HRV positive, of which 60 were pediatric patients. HRV-A was identified in 41 (54%) patients, HRV-B in 6 patients (7.9%) and HRV-C in 29 patients (38%). A total of 47 different genotypes were identified. HRV infections were predominant during fall and winter seasons. 21.1% were affected by HRV alone and 78.9% were found to be co-infected with other microorganisms. The detection rate of HRV in children (18.6%) was significantly higher than in adults (9.6%). Compared with pediatric patients, adult patients were significantly associated with underlying disease, Pneumocystis jirovesii pneumonia co-infection, a diagnosis of pneumonia, fatal outcome, hospital acquisition of HRV, antibiotics administration and requiring intensive care, while pediatric patients were significantly associated with viral co-infection.
HRV was a common cause of respiratory tract infection in Taiwan, particularly in pediatric patients. Eighty percent of HRV-infected inpatients had other microorganisms co-infection. Adult patients were more likely to be associated with a severe respiratory disease entity.
人类鼻病毒（HRV）可导致住院患者发生严重疾病。然而，目前尚无关于 HRV 感染流行情况的研究，尤其是在台湾地区，尚未报道有关住院患者 HRV-C 感染的情况。
回顾性检测了 2013 年至 2014 年期间台湾北部一家医疗中心指定病房的 487 例住院患者的呼吸道标本中是否存在 HRV。对阳性标本进一步进行基因分型检测。回顾性分析 HRV 阳性患者的病历。
共有 76 例患者（15.6%）HRV 阳性，其中 60 例为儿科患者。41 例（54%）患者为 HRV-A 型，6 例（7.9%）患者为 HRV-B 型，29 例（38%）患者为 HRV-C 型。共鉴定出 47 种不同的基因型。HRV 感染主要发生在秋季和冬季。21.1%的患者为单纯 HRV 感染，78.9%的患者合并其他微生物感染。儿童（18.6%）HRV 检出率明显高于成人（9.6%）。与儿科患者相比，成人患者与基础疾病、卡氏肺孢子虫肺炎合并感染、肺炎诊断、不良结局、医院获得性 HRV、抗生素治疗和需要重症监护治疗显著相关，而儿科患者则与病毒合并感染显著相关。
HRV 是台湾地区呼吸道感染的常见病因，尤其是在儿科患者中。80%的 HRV 感染住院患者合并其他微生物感染。成人患者更易发生严重的呼吸道疾病。
